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Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. [5] The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. [6]
CXCL10 is secreted by several cell types in response to IFN-γ.These cell types include monocytes, endothelial cells and fibroblasts. [5] CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and ...
15980 Ensembl ENSG00000159128 ENSG00000262795 ENSMUSG00000022965 UniProt P38484 n/a RefSeq (mRNA) NM_005534 NM_001329128 NM_008338 RefSeq (protein) NP_001316057 NP_005525 n/a Location (UCSC) Chr 21: 33.4 – 33.48 Mb Chr 16: 91.34 – 91.36 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon gamma receptor 2 also known as IFN-γR2 is a protein which in humans is encoded by the ...
The severity of GvHD is highly variable and is influenced by the amount of native cells present in the environment along with other regulatory T cells, T H 1, T H 2, or T H 17 phenotypes. [10] Both CD4 + and CD8 IL-17 producing T cells have been shown to cause aTH1, causing tissue inflammation and resulting in severe GVHD.
They showed that human beta interferon was an unusually hydrophobic glycoprotein. This explained the large loss of interferon activity when preparations were transferred from test tube to test tube or from vessel to vessel during purification. The analyses showed the reality of interferon activity by chemical verification.
Interferon-γ (IFN-γ) release assays rely on the fact that T-lymphocytes will release IFN-γ when exposed to specific antigens. These tests are mostly developed for the field of tuberculosis diagnosis , but in theory, may be used in the diagnosis of other diseases that rely on cell-mediated immunity, e.g. cytomegalovirus and leishmaniasis and ...
The human interferon-gamma receptor complex consists the heterodimer of two chains: IFNGR1 and IFNGR2. [2] [3] In unstimulated cells, these subunits are not preassociated with each other but rather associate through their intracellular domains with inactive forms of specific Janus family kinases (Jak1 and Jak2). Jak1 and Jak2 constitutively ...
After incubation of the blood with antigens for 16 to 24 hours, the amount of interferon-gamma (IFN-gamma) is measured. If the patient is infected with M. tuberculosis, their white blood cells will release IFN-gamma in response to contact with the TB antigens. The QFT-G results are based on the amount of IFN-gamma that is released in response ...