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Malignant hyperthermia is diagnosed on clinical grounds, but various laboratory investigations may prove confirmatory. These include a raised creatine kinase level, elevated potassium, increased phosphate (leading to decreased calcium) and—if determined—raised myoglobin; this is the result of damage to muscle cells.
Sugammadex, sold under the brand name Bridion, is a medication for the reversal of neuromuscular blockade induced by rocuronium and vecuronium [5] in general anaesthesia.It is the first selective relaxant binding agent (SRBA).
As a result, it is contraindicated for patients with susceptibility to malignant hyperthermia, denervating conditions, major burns after 48 hours, and severe hyperkalemia. For nondepolarizing NMBAs except vecuronium, pipecuronium, doxacurium, cisatracurium, rocuronium and rapacuronium, they produce certain extent of cardiovascular effect. [ 14 ]
patients with active hepatic disease; patients in whom spasticity is utilized to maintain upright posture and balance; patients with a hypersensitivity to dantrolene; There are no contraindications for intravenous dantrolene used for prophylaxis or management of malignant hyperthermia. [14]
The diagnosis is suggested on patients with a history of drug exposure to the most common inducing agents such as strong antidopaminergic medications. [6] [40] The differential diagnosis includes serotonin syndrome, [41] encephalitis, toxic encephalopathy, status epilepticus, heat stroke, catatonia and malignant hyperthermia.
Antidotes for anticoagulants are sometimes referred to as reversal agents. [ 3 ] The antidotes for some particular toxins are manufactured by injecting the toxin into an animal in small doses and extracting the resulting antibodies from the host animals' blood.
A muscarinic acetylcholine receptor antagonist, also simply known as a muscarinic antagonist or as an antimuscarinic agent, is a type of anticholinergic drug that blocks the activity of the muscarinic acetylcholine receptors (mAChRs). The muscarinic receptors are proteins involved in the transmission of signals through certain parts of the ...
Lymphoma and a variety of autoimmune diseases, although it may be ineffective in treating IgA-mediated diseases. [ 13 ] Cardiac arrest , cytokine release syndrome , tumor lysis syndrome and acute kidney injury , infections, [ 14 ] hepatitis B reactivation, immune toxicity, pulmonary toxicity, [ 15 ] bowel obstruction and perforation [ 16 ] [ 17 ...