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Initiation and progression of lung carcinoma is the result of the interaction between genetic, epigenetic and environmental factors. Most cases of lung cancer are because of genetic mutations in EGFR, KRAS, STK11 (also known as LKB1), TP53 (also known as p53), and CDKN2A (also known as p16 or INK4a) [117] [118] [119] with the most common type ...
Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes.It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
Clinical Cancer Research is a peer-reviewed medical journal on oncology, including the cellular and molecular characterization, prevention, diagnosis, and therapy of human cancer, medical and hematological oncology, radiation therapy, pediatric oncology, pathology, surgical oncology, and clinical genetics.
Cancer Epidemiology, Biomarkers & Prevention is a peer-reviewed medical journal devoted to research in the field of cancer epidemiology.Topics include descriptive, analytical, biochemical, and molecular epidemiology, the use of biomarkers to study the neoplastic and preneoplastic processes in humans, chemoprevention and other types of prevention trials, and the role of behavioral factors in ...
Gene expression profiling is a technique used in molecular biology to query the expression of thousands of genes simultaneously. While almost all cells in an organism contain the entire genome of the organism, only a small subset of those genes is expressed as messenger RNA (mRNA) at any given time, and their relative expression can be evaluated.
Genes, Chromosomes & Cancer is a monthly peer-reviewed academic journal published by Wiley-Blackwell. According to the Journal Citation Reports , the journal has a 2014 impact factor of 4.041. [ 1 ]
The prototypic oncoantigen is HER2/neu, a membrane tyrosine kinase similar to the epidermal growth factor receptor (EGFR, or HER-1), expressed in about one-fourth of breast cancers. Vaccines against HER2/neu were shown to prevent mammary carcinoma in HER2/neu transgenic mice [4] and are being tested for cancer therapy in humans.
The Journal of Gene Medicine is a monthly peer-reviewed medical journal covering gene therapy and other uses of genetic technologies for medical purposes. It was established in 1999 and is published by John Wiley & Sons. The editors-in-chief is Gening Jiang (Tongji University).