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The tumor suppressing BRCA genes frequently help in cancer prevention. They control how cells divide and develop and help repair DNA damage BRCA gene abnormalities, however, can the likelihood of having specific cancers is raised. Cancers BRCA1 and BRCA2 are the two BRCA recognized cancer-causing gene alterations.
Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes.It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
This gives a wider and more global view of cancer genetics, while these data are usually dispersed. [3] It includes a large iconography of about 35,000 images. Dan van Dyke said "This is one stop shopping that unifies cancer genetics information", and Lidia Larizza said that the Atlas was an "interdisciplinary resource".
Lung cancer is the second most common type of cancer and leading cause of death in men and women in the United States, it is estimated that there is about 216,000 new cases and 160,000 deaths due to lung cancer. [116] Initiation and progression of lung carcinoma is the result of the interaction between genetic, epigenetic and environmental factors.
Gene therapy is used to reinstate the function of a mutated or deleted gene type. When tumor suppressor genes are altered in a way that results in less or no expression, several severe problems can arise for the host. This is why tumor suppressor genes have commonly been studied and used for gene therapy.
Cancer research is research into cancer to identify causes and develop strategies for prevention, diagnosis, treatment, and cure. Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatments.
The European Journal of Cancer Prevention (print: ISSN 0959-8278, online: ISSN 1473-5709) is the official journal of the European Cancer Prevention Organization. It was established in 1991 and is published bimonthly by Lippincott Williams & Wilkins.
Genes, Chromosomes & Cancer is a monthly peer-reviewed academic journal published by Wiley-Blackwell. According to the Journal Citation Reports , the journal has a 2014 impact factor of 4.041. [ 1 ]