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Acute generalized exanthematous pustulosis (AGEP; also known as pustular drug eruption and toxic pustuloderma) is a rare skin reaction that in 90% of cases is related to medication.
There is ongoing research into several potential benefits of candesartan beyond established indications. Candesartan is being investigated for its neuroprotective and anti-inflammatory properties. In an early Alzheimer's disease mouse model , candesartan significantly reduced amyloid burden and inflammation [ 22 ] and it is being examined as a ...
Along with the UK Cochrane Centre, the centre was originally created as part of the Information Systems Strategy of the NHS Research and Development Programme. The original aims of the centre were: To carry out and commission systematic reviews of research findings on the effectiveness and cost effectiveness of health care relevant to the NHS
[8] Candesartan is used experimentally in preventive treatment of migraine. [9] [10] Lisinopril has been found less often effective than candesartan at preventing migraine. [11] The angiotensin II receptor blockers have differing potencies in relation to blood pressure control, with statistically differing effects at the maximal doses. [12]
Candesartan cilexetil (TCV 116) is a benzimidazole which was developed at Takeda and is an ester carbonate prodrug. In vivo, it is rapidly converted to the much more potent corresponding 7-carboxylic acid, candesartan. In the interaction of candesartan with AT 1 receptor the carboxyl group of the benzimidazole ring plays an important role ...
The NIHR (originally named National Institute for Health Research) was created in April 2006 under the government's health research strategy, Best Research for Best Health. [7] This strategy outlined the direction that NIHR research and development should take. Its predecessor was the NHS Research & Development programme which was established ...
Health Research Authority logo. The Health Research Authority (HRA) is an arm's length body of the Department of Health and Social Care (DHSC) in England. [1] The HRA exists to provide a unified national system for the governance of health research. The current chair of the HRA is Professor Sir Terence Stephenson, who succeeded Sir Jonathan ...
Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of fevers, joint pain, and a distinctive salmon-colored bumpy rash. The disease is considered a diagnosis of exclusion. [1] Levels of the iron-binding protein ferritin may be extremely elevated with this ...