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  2. Methods to investigate protein–protein interactions - Wikipedia

    en.wikipedia.org/wiki/Methods_to_investigate...

    Interactions detected by this approach are considered to be real. However, this method can only verify interactions between suspected interaction partners. Thus, it is not a screening approach. A note of caution also is that immunoprecipitation experiments reveal direct and indirect interactions.

  3. Protein–protein interaction - Wikipedia

    en.wikipedia.org/wiki/Protein–protein_interaction

    A correlating phenotypic relationship (i.e. where the inhibition of either of two proteins results in the same phenotype) indicates a positive, or activating relationship. Phenotypes that do not correlate (i.e. where the inhibition of either of two proteins results in two different phenotypes) indicate a negative or inactivating relationship.

  4. Mediation (statistics) - Wikipedia

    en.wikipedia.org/wiki/Mediation_(statistics)

    Simple mediation model. The independent variable causes the mediator variable; the mediator variable causes the dependent variable. In statistics, a mediation model seeks to identify and explain the mechanism or process that underlies an observed relationship between an independent variable and a dependent variable via the inclusion of a third hypothetical variable, known as a mediator ...

  5. Path analysis (statistics) - Wikipedia

    en.wikipedia.org/wiki/Path_analysis_(statistics)

    In statistics, path analysis is used to describe the directed dependencies among a set of variables. This includes models equivalent to any form of multiple regression analysis, factor analysis, canonical correlation analysis, discriminant analysis, as well as more general families of models in the multivariate analysis of variance and covariance analyses (MANOVA, ANOVA, ANCOVA).

  6. Site-directed mutagenesis - Wikipedia

    en.wikipedia.org/wiki/Site-directed_mutagenesis

    Furthermore, the template used is methylated while the mutant strand is unmethylated, and the mutants may be counter-selected due to presence of mismatch repair system that favors the methylated template DNA, resulting in fewer mutants. Many approaches have since been developed to improve the efficiency of mutagenesis.

  7. Direct and indirect realism - Wikipedia

    en.wikipedia.org/wiki/Direct_and_indirect_realism

    Direct realism, also known as naïve realism, argues we perceive the world directly. In the philosophy of perception and philosophy of mind, direct or naïve realism, as opposed to indirect or representational realism, are differing models that describe the nature of conscious experiences; [1] [2] out of the metaphysical question of whether the world we see around us is the real world itself ...

  8. Inverted repeat - Wikipedia

    en.wikipedia.org/wiki/Inverted_repeat

    A direct repeat occurs when a sequence is repeated with the same pattern downstream. [1] There is no inversion and no reverse complement associated with a direct repeat. The nucleotide sequence written in bold characters signifies the repeated sequence. It may or may not have intervening nucleotides. 5´ TTACGnnnnnnTTACG 3´ 3 ...

  9. Reciprocity (evolution) - Wikipedia

    en.wikipedia.org/wiki/Reciprocity_(evolution)

    Direct reciprocity was proposed by Robert Trivers as a mechanism for the evolution of cooperation. [1] If there are repeated encounters between the same two players in an evolutionary game in which each of them can choose either to "cooperate" or "defect", then a strategy of mutual cooperation may be favoured even if it pays each player, in the short term, to defect when the other cooperates.