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Whipple's disease is a rare systemic infectious disease caused by the bacterium Tropheryma whipplei.First described by George Hoyt Whipple in 1907 and commonly considered as a gastrointestinal disorder, Whipple's disease primarily causes malabsorption, but may affect any part of the human body, including the heart, brain, joints, skin, lungs and the eyes. [1]
Whipple's triad is a collection of three signs (called Whipple's criteria) that suggests that a patient's symptoms result from hypoglycaemia that may indicate insulinoma. The essential conditions are symptoms of hypoglycaemia, low blood plasma glucose concentration , and relief of symptoms when plasma glucose concentration is increased.
"Tropheryma whipplei" is a bacterium that is the causative organism of Whipple's disease, [1] and rarely, endocarditis. While "T. whipplei" is categorized with the Gram-positive Actinomycetota, the organism is commonly found to be Gram-positive or Gram-indeterminate when stained in the laboratory. [1]
Causes: Medications (insulin, glinides and sulfonylureas), sepsis, kidney failure, certain tumors, liver disease, [1] [6] malnutrition [7] Diagnostic method: Whipple's triad: Symptoms of hypoglycemia, serum blood glucose level <70 mg/dL (3.9 mmol/L), and resolution of symptoms when blood glucose returns to normal [2] Treatment: Eating foods ...
This article provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed ...
Contagious disease, a subset of infectious diseases. Cryptogenic disease, a disease whose cause is currently unknown. Disseminated disease, a disease that is spread throughout the body. Environmental disease; Lifestyle disease, a disease caused largely by lifestyle choices. Localized disease, a disease affecting one body part or area.
The absence of a pathognomonic sign does not rule out the disease. Labelling a sign or symptom "pathognomonic" represents a marked intensification of a "diagnostic" sign or symptom. The word is an adjective of Greek origin derived from πάθος pathos 'disease' and γνώμων gnomon 'indicator' (from γιγνώσκω gignosko 'I know, I ...
Other gastrointestinal disorders like Whipple's disease, celiac disease, and intestinal bypass surgery for severe obesity can also cause joint involvement. The pathogenesis of arthritis in these conditions is likely influenced by immunologic, genetic, and abnormal bowel permeability factors, though the precise mechanisms are still unknown.