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The term cytokeratin began to be used in the late 1970s, when the protein subunits of keratin intermediate filaments inside cells were first being identified and characterized. [2] In 2006 a new systematic nomenclature for mammalian keratins was created, and the proteins previously called cytokeratins are simply called keratins (human ...
Keratin 14 was the first type I keratin sequence determined. [5] Keratin 14 is also known as cytokeratin-14 (CK-14) or keratin-14 (KRT14). In humans it is encoded by the KRT14 gene. [6] [7] [8] Keratin 14 is usually found as a heterodimer with type II keratin 5 and form the cytoskeleton of epithelial cells.
34βE12, often written as 34betaE12 and also known as CK34βE12 and keratin 903 (CK903), is an antibody specific for high molecular weight cytokeratins 1, 5, 10 and 14. [ 1 ] [ 2 ] It is sometimes, less precisely, referred to as high-molecular weight keratin ( HMWK ) and high-molecular weight cytokeratin ( HMWCK ).
Keratin filaments are abundant in keratinocytes in the hornified layer of the epidermis; these are proteins which have undergone keratinization. They are also present in epithelial cells in general. For example, mouse thymic epithelial cells react with antibodies for keratin 5, keratin 8, and keratin 14.
- The right panel shows high magnification on a positive area, confirming adenocarcinoma, as it shows tumor cells with large nuclei and prominent nucleoli. AE1/AE3 is an antibody cocktail that is used in immunohistochemistry , being generally positive in the cytoplasm of carcinomas (cancers of epithelial origin).
The primary function of keratinocytes is the formation of a barrier against environmental damage by heat, UV radiation, dehydration, pathogenic bacteria, fungi, parasites, and viruses.
For moderate to severe cases, the affected areas should be hydrated (moisturised) with warm water or compresses for 5-10 minutes. Softening preparations are then applied once a day until the excess keratin is removed. In dogs with severe hyperkeratosis and a significant excess of keratin, it is removed with scissors or a blade.
n/a Ensembl ENSG00000143631 n/a UniProt P20930 n/a RefSeq (mRNA) NM_002016 n/a RefSeq (protein) NP_002007 n/a Location (UCSC) Chr 1: 152.3 – 152.33 Mb n/a PubMed search n/a Wikidata View/Edit Human Filaggrin (fil ament aggr egating prote in) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolyzed ...