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A common complaint among patients with cold agglutinin disease is painful fingers and toes with purplish discoloration associated with cold exposure. In chronic cold agglutinin disease, the patient is more symptomatic during the colder months. Cold agglutinin-mediated acrocyanosis differs from Raynaud phenomenon.
Along with hypothyroidism, which impacts your body’s metabolism and can make you feel cold, Raynaud’s disease is another common cause of chilly hands. “This condition commonly occurs in ...
The 66-year-old, who lives near Eye, in Suffolk, had already been diagnosed with the autoimmune condition Scleroderma - which caused stiff skin and inflammation - but he noticed how cold his ...
It can manifest in many symptoms, such as cold hands and feet, and is often associated with low blood pressure. In certain cases it is associated with or predisposes to the development of diseases such as a normal tension glaucoma. [2] Flammer syndrome is named after the Swiss ophthalmologist Josef Flammer.
The condition, which can be a disease, syndrome or phenomenon, causes blood vessels to narrow in response to cold or stress so that little or no blood flows to the affected body parts — most ...
[2] [6] [8] The disease can be either localized to the skin or involve other organs, as well. [2] Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with cold exposure. [1]
Acrocyanosis may be a sign of a more serious medical problem, such as connective tissue diseases and diseases associated with central cyanosis. Other causative conditions include infections, toxicities, antiphospholipid syndrome, cryoglobulinemia, neoplasms. In these cases, the observed cutaneous changes are known as "secondary acrocyanosis".
Causes Mutations in the fibrillin-2 gene, in chromosome 5q23, or the fibrillin-1 gene, at chromosome 15q21.1 Arachnodactyly (" spider fingers ") is a medical condition that is characterized by fingers and toes that are abnormally long and slender, in comparison to the palm of the hand and arch of the foot.