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Digital pathology is a major part of pathology informatics, and encompasses topics including slide scanning, digital imaging, image analysis and telepathology.. Digital pathology is a sub-field of pathology that focuses on managing and analyzing information generated from digitized specimen slides.
The Haversian canals surround blood vessels and nerve cells throughout bones and communicate with osteocytes (contained in spaces within the dense bone matrix called lacunae) through connections called canaliculi. This unique arrangement is conducive to mineral salt deposits and storage which gives bone tissue its strength.
Cancellous bone or spongy bone, [12] [11] also known as trabecular bone, is the internal tissue of the skeletal bone and is an open cell porous network that follows the material properties of biofoams. [13] [14] Cancellous bone has a higher surface-area-to-volume ratio than cortical bone and it is less dense. This makes it weaker and more flexible.
Similar to the frozen section procedure employed in medicine, cryosectioning is a method to rapidly freeze, cut, and mount sections of tissue for histology. The tissue is usually sectioned on a cryostat or freezing microtome. [12] The frozen sections are mounted on a glass slide and may be stained to enhance the contrast between different tissues.
A microscope slide prepared in 1855 containing reference specimens from the inner mucosa of the small intestine of a cholera victim.. The origin of the concept was pieces of ivory or bone, containing specimens held between disks of transparent mica, that would slide into the gap between the stage and the objective. [1]
The endosteum (pl.: endostea) is a thin vascular membrane of connective tissue that lines the inner surface of the bony tissue that forms the medullary cavity of long bones. [1] [2] This endosteal surface is usually resorbed during long periods of malnutrition, resulting in less cortical thickness. [3]
The glass slide can then be stained and examined. This is feasible for an initial evaluation of suspected lymphomas. An initial evaluation of a suspected lymphoma is to make a "touch prep" wherein a glass slide is lightly pressed against excised lymphoid tissue, and subsequently stained (usually H&E stain) for evaluation under light microscopy.
The initiation of endochondral ossification starts by proliferation and condensation of mesenchymal cells in the area where the bone will eventually be formed. Subsequently, these mesenchymal progenitor cells differentiate into chondroblasts, which actively synthesize cartilage matrix components.
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