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LCIS is identified in 0.5% to 1.5% of benign breast biopsies. These biopsies are often done in response to suspicious mammographic findings, as discussed in the Diagnosis section of this article. LCIS is identified in 1.8% to 2.5% of all breast biopsies (including those that show histologic evidence of other lobular or ductal neoplasia. [13]
Round or ovoid cells with little cytoplasm in a single-file infiltrating pattern, sometimes concentrically giving a targetoid pattern Mixed 40% No dominant pattern Solid 10% Sheets of classical-appearing cells with little intervening stroma: Alveolar 5% Aggregates of classical-appearing cells Tubulolobular 5%
Immunohistochemical staining is used to establish receptor status, and the presence or absence of pertinent genes is determined by DNA testing. This article will discuss the features specific to invasive carcinoma NST. More general and complete discussions can be found in articles on breast cancer screening and breast cancer classification.
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Stage 0 which is in situ disease or Paget's disease of the nipple. Stage 0 is a pre-cancerous or marker condition, either ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS). Stages 1–3 are within the breast or regional lymph nodes. Stage 4 is a metastatic cancer. Metastatic breast cancer has a less favorable prognosis ...
There is some controversy as to whether these cancer cells travel through the ductal system of the breast to the nipple, [9] or whether these cells result from in situ malignant transformation. [ 2 ] The most widely accepted theory of how Paget's disease of the breast arises is the migratory theory: ductal carcinoma in situ cancerous cells ...
Carcinoma in situ (CIS) is a group of abnormal cells. [ 1 ] [ 2 ] While they are a form of neoplasm , [ 3 ] there is disagreement over whether CIS should be classified as cancer . This controversy also depends on the exact CIS in question (e.g., cervical, skin, breast).
Mammography is a common screening method, since it is relatively fast and widely available in developed countries. Mammography is a type of radiography used on the breasts. . It is typically used for two purposes: to aid in the diagnosis of a woman who is experiencing symptoms or has been called back for follow-up views (called diagnostic mammography), and for medical screening of apparently ...