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The insufflation of cocaine crystals may also cause physical trauma to epithelial cells, leading to inflammatory lesions, which may also worsen due to the tendency for patients to physically remove the scabs produced in the damaged tissue, which induces further mechanical damage.
Cocaine increases alertness, feelings of well-being, euphoria, energy, sociability, and sexuality. The former are some of the desired effects of cocaine intoxication. Not having the normal use of mental faculties by reason of the introduction of cocaine is defined drug intoxication by the laws in America, Europe, and most of the rest of the World, and it is a serious crime in specific contexts ...
Contact high is a phenomenon that occurs in otherwise sober people who experience a drug-like effect just by coming into contact with someone who is under the influence of a psychoactive drug. In a similar way to the placebo effect, a contact high may be caused by classical conditioning as well as by the physical and social setting. [8] [9]
In the United States, past year cocaine users in 2019 was 5.5 million for people aged 12 or older. When broken into age groups, ages 12–17 had 97,000 users; ages 18–25 had 1.8 million users and ages 26 or older had 3.6 million users. [10] Past year cocaine users with a cocaine use disorder in 2019 was 1 million for people aged 12 or older.
Substance-related disorders, also known as substance use disorders, are a type of mental disorder that affects a person's brain and behavior, leading to their inability to control their use of substances like legal or illegal drugs, alcohol, or medications. The disorders can lead to large societal problems.
Levamisole has become a common additive to illicit cocaine. It is thought to intensify the "high" by releasing dopamine in the brain, acts as a bulking agent, and is a difficult adulterant to recognize. Potential risks of levamisole-laced cocaine include neutropenia, agranulocytosis, arthralgias, retiform purpura, skin necrosis, and fever.
dependence – an adaptive state associated with a withdrawal syndrome upon cessation of repeated exposure to a stimulus (e.g., drug intake) drug sensitization or reverse tolerance – the escalating effect of a drug resulting from repeated administration at a given dose; drug withdrawal – symptoms that occur upon cessation of repeated drug use
Magnan's sign is a clinical sign in which people with cocaine addiction experience paraesthesia which feels like a constantly moving foreign body, such as fine sand or powder, under the skin. [ 1 ] The sign is named after Valentin Magnan .