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U-500 insulin is Public Enemy #1 on the ISMP list. This post dispels the mystery behind concentrated insulin and helps you avoid errors when it comes across your computer screen (or on your NAPLEX)
Humulin R U-500 is a kind of insulin that is much stronger than the more common U-100 insulin. It is used by people with diabetes who need large doses of insulin, usually because they are “insulin resistant.”
Humulin R U-500 is a concentrated insulin. U-500 is 5 times more concentrated than standard U-100 insulin. When insulin is concentrated, it takes less liquid per dose than standard U-100 insulin to help reduce your blood sugar levels. With U-500, you can inject up to 80% less liquid and still get the dose you need.
U-500 insulin is five times more concentrated than regular U-100 insulin. U-500 insulin is used to improve blood sugar control in adults and children with diabetes mellitus who have significant daily insulin needs (more than 200 units per day).
24-week, open-label, randomized trial to compare the efficacy and safety of 2 dosing regimens (TID, n=162 vs BID, n=163) for U-500 insulin replacing high-dose U-100 insulin (>200 units per day) with or without oral antihyperglycemic drugs in adult patients with uncontrolled type 2 diabetes.
Humulin ® (HUE-mu-lin) R U-500 (500 units/mL) is for adults and children who need more than 200 units of insulin in a day to control high blood sugar for their diabetes mellitus. It is more concentrated than Humulin R U-100.
Humulin R U-500 is a prescription medication that’s used to manage blood sugar levels in certain adults and children. Specifically, it’s used in people with type 1 or type 2 diabetes who need...
What is U-500 Insulin? U-500 insulin is a stronger form of insulin. It is used by people who need high doses of insulin. U-500 insulin package. How does U-500 insulin compare to U-100 insulin? U-500 insulin: . • Is 5 times stronger than U-100 insulin (R-insulin). • Lasts at least 8 to 10 hours, which is longer than U-100 insulin lasts.
The introduction of sulfated insulin in the 1970s and the availability of human insulin preparations starting in the 1980s has shifted the use of U-500 insulin to patients with extreme forms of insulin resistance. 1, 2 With the prevalence of obesity and the growing epidemic of type 2 diabetes, the utility of U-500 insulin can be expanded from sy...
Unlike other insulins, U-500 covers both the basal and prandial insulin needs of patients. This unique PK/PD profile allows for its use as monotherapy, and patients can inject smaller volumes with fewer injections compared to therapy with U-100 insulin.