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Anemia (also spelled anaemia in British English) is a blood disorder in which the blood has a reduced ability to carry oxygen.This can be due to a lower than normal number of red blood cells, a reduction in the amount of hemoglobin available for oxygen transport, or abnormalities in hemoglobin that impair its function.
Drop in hemoglobin level, fever, jaundice, or hemoglobinuria, as well as chills, abdominal pain, or back pain: Usual onset: Generally up to one month: Causes: Transfusion of mismatched blood types, reactivity of recipient's antibodies against donor's red blood cell proteins, or prior damage to red blood cells contained in transfusion products ...
A 2013 study of over 400,000 people admitted to US hospitals found that 74% developed anemia at some point during their hospital stay. [5] Iatrogenic anemia is of particular concern in intensive care medicine, [6]: 629 because people who are critically ill require frequent blood tests and have a higher risk of developing anemia due to lower hemoglobin levels and impaired production of red ...
A hemoglobin test measures the amount of hemoglobin in your blood. If a hemoglobin tests shows that a person's levels are below normal, it means they have a low red blood cell count, which is known as anemia. If the test shows higher levels than normal, it means they have hemoglobinemia. [citation needed] The normal range for hemoglobin is:
Beta-thalassemia (β-thalassemia) is an autosomal dominant blood condition that results in the reduction of hemoglobin production. The cause for the disorder is related to a genetic mutation of the HBB gene. This gene is responsible for providing the instructions to produce beta-globin; one of the major components of hemoglobin.
[44] [45] [46] Free hemoglobin can bind to haptoglobin, and the complex is cleared from the circulation; thus, a decrease in haptoglobin can support a diagnosis of hemolytic anemia. Alternatively, hemoglobin may oxidize and release the heme group that is able to bind to either albumin or hemopexin.
Menstrual bleeding is a common cause of iron deficiency anemia in women of childbearing age. [28] Women with menorrhagia (heavy menstrual periods) are at risk of iron deficiency anemia because they are at higher than normal risk of losing more iron during menstruation than is replaced in their diet. Most women lose about 40 mL of blood per cycle.
This is the most common human hemoglobin tetramer, accounting for over 97% of the total red blood cell hemoglobin in normal adults. [55] hemoglobin A2, (HbA2) is a second form of adult hemoglobin and is composed of two alpha and two delta chains. This hemoglobin typically makes up 1-3% of hemoglobin in adults. [55]
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