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A paraganglioma is a rare neuroendocrine neoplasm that may ... The sustentacular cells are S-100 positive and focally positive for glial ... This sign is known as ...
Micrograph highlighting the sustentacular cells in a paraganglioma. S100 immunostain. A sustentacular cell is a type of cell primarily associated with structural support, they can be found in various tissues.
The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation. At least 21 different S100 proteins are known. [1] They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1, S100A2, S100A3.
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Paraganglioma (j) typically shows negativity for calcitonin and S100-positive sustentacular cells (inset) [9] Hyperfunctioning follicular adenoma typically shows follicles with papillary infoldings and bubbly, pale colloid with peripheral scalloping (a).
Finland handed the defending champion United States its first loss at the 2025 world junior hockey championship as Tuomas Uronen scored in overtime for a 4-3 win on Sunday afternoon.
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Glomus tumors are usually solitary and small lesions. The vast majority are found in the hand, wrist, foot, and under the fingernails. [3]They are often painful, and the pain is reproduced when the lesion is placed in cold water - a history of sensitivity to cold weather is also common. [6]