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[7] [8] Research has shown that not only does the SC form after genetic recombination but mutant yeast cells unable to assemble a synaptonemal complex can still engage in the exchange of genetic information. However, in other organisms like the C. elegans nematode, formation of chiasmata require the formation of the synaptonemal complex.
In genetics, a chiasma (pl.: chiasmata) is the point of contact, the physical link, between two (non-sister) chromatids belonging to homologous chromosomes. At a given chiasma, an exchange of genetic material can occur between both chromatids, what is called a chromosomal crossover , but this is much more frequent during meiosis than mitosis ...
The synaptonemal complex (SC) is a key protein structure that physically holds homologous chromosomes together during prophase I of meiosis I, facilitating their alignment and the pairing of homologs, named synapsis. [6]
The anchorage of the cytoskeleton to the chromosomes takes place at the centromere thanks to a protein complex called kinetochore. This tension results in the alignment of the bivalent at the center of the cell, the chiasmata and the distal cohesion of the sister chromatids being the anchor point sustaining the force exerted on the whole structure.
Chromosomes are linear arrangements of condensed deoxyribonucleic acid (DNA) and histone proteins, which form a complex called chromatin. [2] Homologous chromosomes are made up of chromosome pairs of approximately the same length, centromere position, and staining pattern, for genes with the same corresponding loci. One homologous chromosome is ...
Achiasmate meiosis refers to meiosis without chiasmata, which are structures that are necessary for recombination to occur and that usually aid in the segregation of non-sister homologs. [1] The pachytene stage of prophase I typically results in the formation of chiasmata between homologous non-sister chromatids in the tetrad chromosomes that ...
In zygotene, the synaptonemal complex forms more extensively between the paired chromosomes. It zips the homologs together along their entire length, with the lateral elements of the complex associated with each chromosome and the central region holding them together. This allows intimate pairing and genetic recombination events. [3] [4]
During the diplotene stage, also known as diplonema, from Greek words meaning "two threads", [18]: 30 the synaptonemal complex disassembles and homologous chromosomes separate from one another a little. However, the homologous chromosomes of each bivalent remain tightly bound at chiasmata, the regions where crossing-over occurred.