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S is the current density (flux) outward through the membrane carried by ion S, measured in amperes per square meter (A·m −2) P S is the permeability of the membrane for ion S measured in m·s −1; z S is the valence of ion S; V m is the transmembrane potential in volts
Ions often move through the segments of the channel pore in a single file nearly as quickly as the ions move through the free solution. In many ion channels, passage through the pore is governed by a "gate", which may be opened or closed in response to chemical or electrical signals, temperature, or mechanical force.
Co 2+ - cobalt ions are present in the human body in amounts from 1 to 2 mg. [4] Cobalt is observed in the heart, liver, kidney, and spleen, and considerably smaller quantities in the pancreas, brain, and serum. [4] [5] Cobalt is a necessary component of vitamin B 12 and a fundamental coenzyme of cell mitosis. [5]
Developmental bioelectricity is a sub-discipline of biology, related to, but distinct from, neurophysiology and bioelectromagnetics.Developmental bioelectricity refers to the endogenous ion fluxes, transmembrane and transepithelial voltage gradients, and electric currents and fields produced and sustained in living cells and tissues.
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In cell biology, ion trapping is the build-up of a higher concentration of a chemical across a cell membrane due to the pKa value of the chemical and difference of pH across the cell membrane. [ 1 ] [ 2 ] This results in basic chemicals accumulating in acidic bodily fluids such as the cytosol , and acidic chemicals accumulating in basic fluids.
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The concept of Hofmeister ionicity I h has been invoked by Dharma-wardana et al. [21] where it is proposed to define I h as a sum over all ionic species, of the product of the ionic concentration (mole fraction) and a fractional number specifying the "Hofmeister strength" of the ion in denaturing a given reference protein.