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A nanogenizer, also known as a high-pressure homogenizer or a microfluidizer, is a device used to create small droplets or particles by applying high pressure to a liquid mixture. [24] These devices can be used to produce nanoemulsions, as well as other types of emulsions and suspensions. [25]
Nanocellulose fibrils (MFC and CNFs) may be isolated from the cellulose fibers using mechanical methods that expose the fibers to high shear forces, delaminating them into nano-fibers. For this purpose, high-pressure homogenizers, grinders or microfluidizers can be used.
Many variations for artificial cell preparation and encapsulation have been developed. Typically, vesicles such as a nanoparticle, polymersome or liposome are synthesized. An emulsion is typically made through the use of high pressure equipment such as a high pressure homogenizer or a Microfluidizer.
Carvedilol-loaded solid lipid nanoparticles were prepared using hot-homogenization technique for oral delivery with compritol and poloxamer 188 as the lipid and surfactant, respectively. [22] Another example of drug delivery using SLN would be oral solid SLN suspended in distilled water, which was synthesized to trap drugs within the SLN structure.
[9] [11] Common synthetic strategies for polymeric nanoparticles include microfluidic approaches, [12] electrodropping, [13] high pressure homogenization, and emulsion-based interfacial polymerization. [14] Polymer biodegradability is an important aspect to consider when choosing the appropriate nanoparticle chemistry.
In solid lipid nanoparticles, the drug molecules are dissolved in the particle's solid hydrophobic lipid core, this is called the drug payload, and it is surrounded by an aqueous solution. [6] Many SLNs are developed from triglycerides, fatty acids, and waxes. High-pressure homogenization or micro-emulsification can be used
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