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  2. Methyltransferase - Wikipedia

    en.wikipedia.org/wiki/Methyltransferase

    2'-O-methylation, m6A methylation, m1G methylation as well as m5C are most commonly methylation marks observed in different types of RNA. 6A is an enzyme that catalyzes chemical reaction as following: [9] S-adenosyl-L-methionine + DNA adenine S-adenosyl-L-homocysteine + DNA 6-methylaminopurine

  3. Differentially methylated region - Wikipedia

    en.wikipedia.org/wiki/Differentially_methylated...

    DNA is mostly methylated at a CpG site, which is a cytosine followed by a guanine. The “p” refers to the phosphate linker between them. The “p” refers to the phosphate linker between them. DMR usually involves adjacent sites or a group of sites close together that have different methylation patterns between samples.

  4. DNA methylation - Wikipedia

    en.wikipedia.org/wiki/DNA_methylation

    [83] [84] DNA methylation marks are mainly on the gene body, and current opinions on the function of DNA methylation is gene regulation via alternative splicing [85] DNA methylation levels in Drosophila melanogaster are nearly undetectable. [86] Sensitive methods applied to Drosophila DNA Suggest levels in the range of 0.1–0.3% of total ...

  5. Methylation - Wikipedia

    en.wikipedia.org/wiki/Methylation

    In mammals, DNA methylation is common in body cells, [7] and methylation of CpG sites seems to be the default. [ 8 ] [ 9 ] Human DNA has about 80–90% of CpG sites methylated, but there are certain areas, known as CpG islands , that are CG-rich (high cytosine and guanine content, made up of about 65% CG residues ), wherein none is methylated.

  6. DNA (cytosine-5)-methyltransferase 3A - Wikipedia

    en.wikipedia.org/wiki/DNA_(cytosine-5)-methyl...

    This enzyme is responsible for de novo DNA methylation. Such function is to be distinguished from maintenance DNA methylation which ensures the fidelity of replication of inherited epigenetic patterns. DNMT3A forms part of the family of DNA methyltransferase enzymes, which consists of the protagonists DNMT1, DNMT3A and DNMT3B. [5] [6]

  7. TET enzymes - Wikipedia

    en.wikipedia.org/wiki/TET_enzymes

    They are instrumental in DNA demethylation. 5-Methylcytosine (see first Figure) is a methylated form of the DNA base cytosine (C) that often regulates gene transcription and has several other functions in the genome. [1] DNA methylation is the addition of a methyl group to the DNA that happens at cytosine. The image shows a cytosine single ring ...

  8. Bayesian tool for methylation analysis - Wikipedia

    en.wikipedia.org/wiki/Bayesian_tool_for...

    Bayesian tool for methylation analysis, also known as BATMAN, is a statistical tool for analysing methylated DNA immunoprecipitation (MeDIP) profiles. It can be applied to large datasets generated using either oligonucleotide arrays (MeDIP-chip) or next-generation sequencing (MeDIP-seq), providing a quantitative estimation of absolute methylation state in a region of interest.

  9. DNA methyltransferase - Wikipedia

    en.wikipedia.org/wiki/DNA_methyltransferase

    In biochemistry, the DNA methyltransferase (DNA MTase, DNMT) family of enzymes catalyze the transfer of a methyl group to DNA. DNA methylation serves a wide variety of biological functions. All the known DNA methyltransferases use S-adenosyl methionine (SAM) as the methyl donor.