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In subcortical dementia, there is targeted damage to regions lying under the cortex. The pathological process that result in subcortical dementia shows neuronal changes that involve primarily the thalamus , basal ganglia , and rostral brain-stem nuclei and mostly, some projections in the white matter from these regions to the cortex, with ...
Binswanger's disease is a type of subcortical vascular dementia caused by white matter atrophy to the brain. However, white matter atrophy alone is not sufficient for this disease; evidence of subcortical dementia is also necessary. [9]
Multi-infarct dementia results from a series of small strokes affecting several brain regions. Stroke-related dementia involving successive small strokes causes a more gradual decline in cognition. [4] Dementia may occur when neurodegenerative and cerebrovascular pathologies are mixed, as in susceptible elderly people (75 years and older).
"It sounds bad, and it is bad," said senior author Dr. Laura J. Bierut, alumni-endowed professor of psychiatry. "A reduction in brain volume is consistent with increased aging.
One other specific age related factor noted in Popescu et al. is a decrease in estrogen as one ages could adversely affect the breakdown of the blood-brain barrier and create a sensitivity to neurodegeneration. [14] As pointed out earlier, dementia is a broad category of memory impairments most commonly associated with ageing.
Researchers from the Karolinska Institutet have found that Alzheimer’s disease medications called cholinesterase inhibitors may help slow down cognitive decline in people with dementia with Lewy ...
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. [2] It is the cause of 60–70% of cases of dementia. [2] [15] The most common early symptom is difficulty in remembering recent events. [1]
Korsakoff syndrome (KS) [1] is a disorder of the central nervous system characterized by amnesia, deficits in explicit memory, and confabulation.This neurological disorder is caused by a deficiency of thiamine (vitamin B 1) in the brain, and it is typically associated with and exacerbated by the prolonged, excessive ingestion of alcohol. [2]