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  2. Pomalidomide - Wikipedia

    en.wikipedia.org/wiki/Pomalidomide

    Pomalidomide, sold under the brand names Pomalyst and Imnovid, [7] [8] is an anti-cancer medication used for the treatment of multiple myeloma and AIDS-related Kaposi sarcoma. [ 7 ] Pomalidomide was approved for medical use in the United States in February 2013, [ 10 ] and in the European Union in August 2013. [ 8 ]

  3. Cereblon E3 ligase modulator - Wikipedia

    en.wikipedia.org/wiki/Cereblon_E3_ligase_modulator

    The thalidomide molecule is a synthetic derivative of glutamic acid and consists of a glutarimide ring and a phthaloyl ring (Figure 5). [15] [16] Its IUPAC name is 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione and it has one chiral center [15] After thalidomide's selective inhibition of TNF-α had been reported, a renewed effort was put in thalidomide's clinical development.

  4. Multiple myeloma - Wikipedia

    en.wikipedia.org/wiki/Multiple_myeloma

    Risk factors include obesity, radiation exposure, family history, age and certain chemicals. [5] [11] [12] There is an increased risk of multiple myeloma in certain occupations. [13] This is due to the occupational exposure to aromatic hydrocarbon solvents having a role in causation of multiple myeloma. [14]

  5. A 'concerning' number of women 65 and older are dying from ...

    www.aol.com/lifestyle/concerning-number-women-65...

    Nearly one in five new cervical cancers diagnosed from 2009 to 2018 were in women 65 and older, according to a new UC Davis study.But what has experts concerned is that, according to the study ...

  6. A group of women lowered their biological age by an average ...

    www.aol.com/finance/group-women-lowered...

    None of the women completed all tasks all days, and that’s okay, researchers wrote. Improvements in biological age were seen among women who adhered to the program an average of 82% of the time.

  7. Kaposi's sarcoma-associated herpesvirus - Wikipedia

    en.wikipedia.org/wiki/Kaposi's_sarcoma-associated...

    A thalidomide analog medicine – Pomalidomide was also granted by the FDA in 2011. Pomalidomide was shown to recover the expression of MHC-1, which help cell display intracellular proteins to cytotoxic T cells, and it also can repress the expression of PD-L1 and increase the CD8+ T cell killing. [49]

  8. Thalidomide - Wikipedia

    en.wikipedia.org/wiki/Thalidomide

    [10] [11] While it was initially thought to be safe in pregnancy, concerns regarding birth defects arose, resulting in its removal from the market in Europe in 1961. [9] [10] The total number of infants severely harmed by thalidomide use during pregnancy is estimated at over 10,000, possibly 20,000, of whom about 40% died around the time of birth.

  9. Lenalidomide - Wikipedia

    en.wikipedia.org/wiki/Lenalidomide

    Lenalidomide is used to treat multiple myeloma. [11] It is a more potent molecular analog of thalidomide, which inhibits tumor angiogenesis, tumor-secreted cytokines, and tumor proliferation through induction of apoptosis.

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