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Benzylamine is used as a masked source of ammonia, since after N-alkylation, the benzyl group can be removed by hydrogenolysis: [10] C 6 H 5 CH 2 NH 2 + 2 RBr → C 6 H 5 CH 2 NR 2 + 2 HBr C 6 H 5 CH 2 NR 2 + H 2 → C 6 H 5 CH 3 + R 2 NH. Typically a base is employed in the first step to absorb the HBr (or related acid for other kinds of ...
1-Phenylethylamine (1-PEA or α-PEA), also known as α-methylbenzylamine, is the organic compound with the formula C 6 H 5 CH(NH 2)CH 3. This primary amine is a colorless liquid is often used in chiral resolutions. Like benzylamine, it is relatively basic and forms stable ammonium salts and imines.
Methylenedioxybenzylamphetamine, abbreviated MDBZ, and systematically named 3,4-methylenedioxy-N-benzylamphetamine, is a psychedelic drug.It is the N-benzyl ...
lic 6 h 4 ch 2 n(ch 3) 2 + e + → 2-ec 6 h 4 ch 2 n(ch 3) 2 Via these reactions, many derivatives are known with the formula 2-X-C 6 H 4 CH 2 N(CH 3 ) 2 (E = SR, PR 2 , etc.). The amine is basic and undergoes quaternization with alkyl halides (e.g. hexyl bromide ) to give quaternary ammonium salts: [ 4 ]
N-Methylphenethylamine (NMPEA) is a naturally occurring trace amine neuromodulator in humans that is derived from the trace amine, phenethylamine (PEA). [2] [3] It has been detected in human urine (<1 μg over 24 hours) [4] and is produced by phenylethanolamine N-methyltransferase with phenethylamine as a substrate, which significantly increases PEA's effects.
N,α-Diethylphenethylamine (DEPEA or NADEP), also known as 2-ethylamino-1-phenylbutane (EAPB) is a stimulant drug of the phenylisobutylamine (α-ethylphenethylamine) group. It is a close chemical analog of methamphetamine , which has been sold as a designer drug .
The structure-activity relationship of the drug class has been explored to a reasonable extent. The optimal substitution pattern is fairly tightly defined (i.e. N,N-diethyl on the amine nitrogen, 4-ethoxy on the benzyl ring and 5-nitro on the benzimidazole ring), but even derivatives incorporating only some of these features are still potent opioids.
Benzylone (also known as 3,4-Methylenedioxy-N-benzylcathinone or BMDP), is a recreational designer drug from the substituted cathinone family, with stimulant effects. It has been commonly encountered in seizures of street drug samples but appears to have relatively low potency on its own, being mainly found as a component of mixtures with other related drugs.