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  2. Promoter activity - Wikipedia

    en.wikipedia.org/wiki/Promoter_activity

    Promoter activity of the P-RM and P-R promoters vs RNA polymerase concentration in the enterobacteriophage lambda [1]. Promoter activity is a term that encompasses several meanings around the process of gene expression from regulatory sequences —promoters [2] and enhancers. [3]

  3. Transcription preinitiation complex - Wikipedia

    en.wikipedia.org/wiki/Transcription_pre...

    Transcription preinitiation complex, represented by the central cluster of proteins, causes RNA polymerase to bind to target DNA site. The PIC is able to bind both the promoter sequence near the gene to be transcribed and an enhancer sequence in a different part of the genome, allowing enhancer sequences to regulate a gene distant from it.

  4. Promoter (genetics) - Wikipedia

    en.wikipedia.org/wiki/Promoter_(genetics)

    In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter. The RNA transcript may encode a protein ( mRNA ), or can have a function in and of itself, such as tRNA or rRNA .

  5. Regulatory sequence - Wikipedia

    en.wikipedia.org/wiki/Regulatory_sequence

    An active enhancer regulatory sequence of DNA is enabled to interact with the promoter DNA regulatory sequence of its target gene by formation of a chromosome loop. This can initiate messenger RNA (mRNA) synthesis by RNA polymerase II (RNAP II) bound to the promoter at the transcription start site of the gene. The loop is stabilized by one ...

  6. General transcription factor - Wikipedia

    en.wikipedia.org/wiki/General_transcription_factor

    A sigma factor is a protein needed only for initiation of RNA synthesis in bacteria. [12] Sigma factors provide promoter recognition specificity to the RNA polymerase (RNAP) and contribute to DNA strand separation, then dissociating from the RNA polymerase core enzyme following transcription initiation. [13]

  7. PTK2 - Wikipedia

    en.wikipedia.org/wiki/PTK2

    PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. [4] PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around). [5]

  8. Distal promoter - Wikipedia

    en.wikipedia.org/wiki/Distal_promoter

    Further research at the late stage of thymocyte development reveals that distal Lck promoter with driven Cre will result in the distal lck gene promoter to drive Cre expression to be limited within innate-like T cells. There is a cell type specific function in innate-like T cells based on the distal lck promoter - driven Cre. [3]

  9. CAAT box - Wikipedia

    en.wikipedia.org/wiki/CAAT_box

    [1] In molecular biology, a CCAAT box (also sometimes abbreviated a CAAT box or CAT box) is a distinct pattern of nucleotides with GGCCAATCT consensus sequence that occur upstream by 60–100 bases to the initial transcription site.

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