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Dimethyl sulfone (DMSO 2) is an organosulfur compound with the formula (CH 3) 2 SO 2. It is also known by several other names including methyl sulfone and (especially in alternative medicine) methylsulfonylmethane (MSM). [4] This colorless solid features the sulfonyl functional group and is the simplest of the sulfones. It is relatively inert ...
[6] [3] MSF, which is a liquid at room temperature, has a vapor pressure of 19.2 mmHg, slightly more volatile than water which has a vapor pressure of 18.8 mmHg at 21 °C. This vapor has an LCt 50 (lethal concentration, 50% death rate in a given time) in rats of between 4 and 5 parts per million (ppm) during one hour of exposure or between 1 ...
The sulfonyl chlorides and fluorides are of dominant importance in this series. [1] [2] Sulfonyl halides have tetrahedral sulfur centres attached to two oxygen atoms, an organic radical, and a halide. In a representative example, methanesulfonyl chloride, the S=O, S−C, and S−Cl bond distances are respectively 142.4, 176.3, and 204.6 pm. [3]
[3] Similar to MsCl, Ms 2 O can perform mesylation of alcohols to form sulfonates. Use of Ms 2 O avoids the alkyl chloride, which often appears as a side-product when MsCl is used. [4] Unlike MsCl, Ms 2 O may not be suitable for mesylation of the unsaturated alcohols. [5] Examples of mesylation of alcohols with Ms 2 O:
Methanesulfonyl chloride is mainly used to give methanesulfonates by its reaction with alcohols in the presence of a non-nucleophilic base. [8] In contrast to the formation of toluenesulfonates from alcohols and p-toluenesulfonyl chloride in the presence of pyridine, the formation of methanesulfonates is believed to proceed via a mechanism wherein methanesulfonyl chloride first undergoes an ...
Trifluoromethanesulfonic anhydride, also known as triflic anhydride, is the chemical compound with the formula (CF 3 SO 2) 2 O. It is the acid anhydride derived from triflic acid . This compound is a strong electrophile , useful for introducing the triflyl group , CF 3 SO 2 .
Methanesulfonic acid (MsOH, MSA) or methanesulphonic acid (in British English) is an organosulfuric, colorless liquid with the molecular formula CH 3 SO 3 H and structure H 3 C−S(=O) 2 −OH. It is the simplest of the alkylsulfonic acids ( R−S(=O) 2 −OH ).
Alternative sulfonyl fluoride reagents like p-APMSF and HDSF, have altered access to native folded protein structures, and may react with serine enzymes that PMSF cannot efficiently react with. This altered selectivity between sulfonyl fluoride reagents has been used to classify and isolate particular types of serine enzymes.