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In men with prostate cancer, the ratio of free (unbound) PSA to total PSA is decreased. The risk of cancer increases if the free to total ratio is less than 25%. (See graph) The lower the ratio is, the greater the probability of prostate cancer. Measuring the ratio of free to total PSA appears to be particularly promising for eliminating ...
The 4Kscore combines total, free and intact PSA together with human kallikrein 2. [46] It is used to try to determine the risk of a Gleason score greater than 6. [46] The Prostate Health Index (PHI) is a PSA-based blood test for early prostate cancer screening. It may be used to determine when a biopsy is needed.
Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder.Abnormal growth of the prostate tissue is usually detected through screening tests, typically blood tests that check for prostate-specific antigen (PSA) levels.
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The likelihood ratio of a test provides a way to estimate the pre- and post-test probabilities of having a condition. With pre-test probability and likelihood ratio given, then, the post-test probabilities can be calculated by the following three steps: [17]
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High nucleus/cytoplasm ratio [1] Irregular or angulated nuclei [1] Euchromatic [1] May have nuclear and cytoplasmic micro-vacuolation [1] Infiltration of adjacent parenchyma [1] BCC-pattern: Variably sized solid nests, cords, or trabeculae [1] Peripheral palisading [1] p63+ [1] HMCK(34βE12)+ [1] Typically CK20−/CK7+, but CK7− in pure solid ...
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