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  2. Tamoxifen - Wikipedia

    en.wikipedia.org/wiki/Tamoxifen

    With time, risk of endometrial cancer may be doubled to quadrupled, which is a reason tamoxifen is typically only used for five years. [50] The American Cancer Society lists tamoxifen as a known carcinogen, stating that it increases the risk of some types of uterine cancer while lowering the risk of breast cancer recurrence. [51]

  3. Endometrial cancer - Wikipedia

    en.wikipedia.org/wiki/Endometrial_cancer

    Tamoxifen, a drug used to treat estrogen-positive breast cancers, has been associated with endometrial cancer in approximately 0.1% of users, particularly older women, but the benefits for survival from tamoxifen generally outweigh the risk of endometrial cancer. [30]

  4. Uterine cancer - Wikipedia

    en.wikipedia.org/wiki/Uterine_cancer

    Treatment of uterine cancer may differ depending on the type of cancer and staging of the tumor. [15] In early stages, minimal invasive surgery is preferred. [16] For endometrial cancer, five main types of treatments are used, including surgery, radiation therapy, chemotherapy, hormone therapy, and targeted therapy

  5. Tackling Cancer: Endometrial Cancer's Biggest Current and ...

    www.aol.com/2013/05/11/tackling-cancer...

    As I noted 10 weeks ago, cancer statistics are both staggering and disappointing. Although cancer deaths per 100,000 people have been on the downswing since 1991 thanks to access to more effective ...

  6. Antihormone therapy - Wikipedia

    en.wikipedia.org/wiki/Antihormone_therapy

    Tamoxifen is also thought to lower the risk of breast cancer in those who have a predisposition or at risk. [9] Tamoxifen may be used in pre and postmenopausal women. [10] Toremifene is a similar SERM drug to tamoxifen, but is less common and only approved for treatment of metastatic cancer. Toremifene is generally prescribed once tamoxifen is ...

  7. Hormonal therapy (oncology) - Wikipedia

    en.wikipedia.org/wiki/Hormonal_therapy_(oncology)

    Tamoxifen is currently first-line treatment for nearly all pre-menopausal women with hormone receptor-positive breast cancer. [1] Raloxifene is another partial agonist SERM which does not seem to promote endometrial cancer, and is used primarily for chemoprevention of breast cancer in high-risk individuals, as well as to prevent osteoporosis. [1]

  8. AstraZeneca Imfinzi plus chemotherapy gets US nod for ... - AOL

    www.aol.com/news/astrazeneca-imfinzi-plus...

    Endometrial cancer ranks as the fourth most prevalent cancer among women in the U.S. In 2022, it affected more than 66,000 patients and was responsible for nearly 12,000 fatalities.

  9. Selective estrogen receptor modulator - Wikipedia

    en.wikipedia.org/wiki/Selective_estrogen...

    Tamoxifen is a pure antiestrogenic trans-isomer and has differential actions at estrogen target tissues throughout the body. Tamoxifen is selectively antiestrogenic in the breast but estrogen-like in bones and endometrial cancer. [24] Tamoxifen undergo phase I metabolism in the liver by microsomal cytochrome P450 (CYP) enzymes.

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