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Polymorphisms in various genes controlling appetite and metabolism predispose to obesity under certain dietary conditions. The percentage of obesity that can be attributed to genetics varies widely, depending on the population examined, from 6% to 85%, [ 6 ] with the typical estimate at 50%.
[60] [61] The thiazolidinediones, on the other hand, may cause weight gain, but decrease central obesity. [62] Diabetics also achieve modest weight loss with fluoxetine and orlistat over 12–57 weeks. [63] Rimonabant (Acomplia), another drug, had been withdrawn from the market. It worked via a specific blockade of the endocannabinoid system.
Set point theory can be construed as implying weight regulation in a wide or tight range around the set point, in a symmetric or in an asymmetric manner (i.e. treating weight gain and loss either the same or differently), and may apply to regulation of body fat levels specifically (in a multi-compartment model) or to overall body weight.
[9] [12] Attaining a healthy weight involves recognition of general techniques such as portion sizing, self-monitoring, and daily diet consistency. [13] Once this healthy weight has been attained, maintaining this stable weight additionally involves physical activity and control of an individual's environment and eating patterns. [14]
[citation needed] Moreover, "The prevalence of obesity for adults aged 20 to 74 years increased by 7.9 percentage points for men and by 8.9 percentage points for women between 1976–1980 and 1988–1994, and subsequently by 7.1 percentage points for men and by 8.1 percentage points for women between 1988–1994 and 1999–2000."
Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat. These medications alter one of the fundamental processes of the human body , weight regulation, by: reducing appetite and consequently energy intake , increasing energy expenditure , redirecting nutrients from adipose to lean ...
According to a 2022 study, weight gain Design: Eat This, Not That!Weight gain during menopause may seem like an unavoidable downside of aging. But the good news is it doesn't have to be.
[40] Body fat percentage is total body fat expressed as a percentage of total body weight. There is no generally accepted definition of obesity based on total body fat. Most researchers have used >25% in men, and >30% in women, as cut-points to define obesity, [41] but the use of these values have been disputed. [42]