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  2. Tramadol - Wikipedia

    en.wikipedia.org/wiki/Tramadol

    Long-term use of high doses of tramadol causes physical dependence and withdrawal syndrome. [37] These include both symptoms typical of opioid withdrawal and those associated with serotonin–norepinephrine reuptake inhibitor (SNRI) withdrawal; symptoms include numbness, tingling, paresthesia, and tinnitus. [38]

  3. List of side effects of tramadol - Wikipedia

    en.wikipedia.org/wiki/List_of_side_effects_of...

    Bradycardia; Hypertension (high blood pressure); Allergic reactions (e.g. dyspnoea (shortness of breath), bronchospasm, wheezing, angioneurotic oedema) Anaphylaxis; Changes in appetite

  4. Pain management in children - Wikipedia

    en.wikipedia.org/wiki/Pain_management_in_children

    Morphine is effective and relatively safe, and is often used with moderate to severe pain. [19] Codeine and tramadol should be avoided especially in children younger than 12 years old since metabolism varies due to genetic differences between individuals, [20] and, in the case of tramadol, this medication has not been well studied in children. [21]

  5. Benzodiazepine withdrawal syndrome - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine_withdrawal...

    Benzodiazepine withdrawal syndrome (BZD withdrawal) is the cluster of signs and symptoms that may emerge when a person who has been taking benzodiazepines as prescribed develops a physical dependence on them and then reduces the dose or stops taking them without a safe taper schedule.

  6. Escitalopram (Lexapro): Everything You Need to Know Before ...

    www.aol.com/escitalopram-lexapro-everything-know...

    In general, large-scale studies do tend to show that long-term use of antidepressants is associated with weight gain side effects. However, study data on escitalopram and weight changes is very ...

  7. N,O-Didesmethyltramadol - Wikipedia

    en.wikipedia.org/wiki/N,O-didesmethyltramadol

    N,O-Didesmethyltramadol (tramadol metabolite M5) is an opioid derivative which is one of two active metabolites of the opioid analgesic medication tramadol.It is many times less potent than the other active metabolite O-Desmethyltramadol but is still more potent as a mu opioid receptor agonist than tramadol itself, unlike the other metabolites N-desmethyltramadol, N,N-didesmethyltramadol, and ...

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  9. Opioid overdose - Wikipedia

    en.wikipedia.org/wiki/Opioid_overdose

    Higher doses of prescription opioids as well as long acting formulations are associated with an increased risk of overdose. [24] In those on long term opioid treatment for chronic pain, daily morphine equivalents greater than 200 mg were associate with death from opioid related causes (including overdose) in 3.8% of men and 2.2% of women. [24]