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The diagnostic criteria are the same for both conditions, except that PDD is distinguished from DLB by the time frame in which dementia symptoms appear relative to parkinsonian symptoms. DLB is diagnosed when cognitive symptoms begin before or at the same time as parkinsonism. Parkinson's disease dementia is the diagnosis when Parkinson's ...
[12] [13] The Lewy body dementias—dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD)—are distinguished by the timing when cognitive and motor symptoms appear. [14] The two Lewy body dementias are often considered to belong on a spectrum of Lewy body disease that includes Parkinson's disease. [2] [5]
“In general, the etiology of dementia in Parkinson’s is thought to be a mix of Lewy body pathology primarily, but, also to varying extents, Alzheimer’s disease pathology and vascular disease ...
Dementia with Lewy bodies and Parkinson's disease dementia are clinically similar after dementia occurs in Parkinson's disease. [151] Delusions in Parkinson's disease dementia are less common than in DLB, [152] and persons with Parkinson's disease are typically less caught up in their visual hallucinations than those with DLB. [85]
The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may trigger cell death. Study of synucleinopathy mouse models of Parkinson's disease indicates that alpha-synuclein pathogenesis is associated with increased DNA damage and activation of the DNA damage response. [19]
In addition to this, a decrease of 20% incidence of Parkinson’s disease, as well as a 19% decrease in incidence of Alzheimer’s disease was observed in the group. Risk of vascular dementia was ...
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