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Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4]
The pharmacokinetics of phentermine are dose-dependent. [ 6 ] [ 6 ] Peak concentrations of phentermine are reached 6 hours following oral administration of a dose of 15 mg. [ 6 ] The steady-state levels of phentermine with continuous administration have been found to be around 200 ng/mL in clinical studies. [ 6 ]
Phentermine and topiramate was developed by Vivus, a California pharmaceutical company. In December 2009, Vivus, Inc. submitted a new drug application (NDA) to the FDA and on 1 March 2010, Vivus, Inc. announced that the FDA accepted the NDA for review.
Originally available only by prescription, it was approved by the FDA for over-the-counter sale in February 2007. [32] In May 2010, the U.S. Food and Drug Administration (FDA) approved a revised label for Xenical to include new safety information about rare cases of severe liver injury that have been reported with the use of this medication. [33]
In his book PiHKAL (Phenethylamines i Have Known And Loved), the dosage range is listed as 160–240 mg, and the duration as 3–5 hours. [1] MDPH's effects are very similar to those of MDA: they both are smooth and "stoning," and do not cause any visuals. They also alter dreams and dream patterns.
Geritol is a United States trademarked name for various dietary supplements, past and present. [1] Geritol is a brand name for several vitamin complexes plus iron or multimineral products in both liquid form and tablets containing from 9.5 to 18 mg of iron per daily dose. [2] The name conveys a connection with aging, as in "geriatric." The ...
Fenfluramine is indicated for the treatment of seizures associated with Dravet syndrome and Lennox–Gastaut syndrome in people age two and older. [3] [7] [4]Dravet syndrome is a life-threatening, rare and chronic form of epilepsy. [7]
Fenproporex (Perphoxene) (N-2-Cyanoethylamphetamine) (3-(1-phenylpropan-2-ylamino)propanenitrile) (3-[(1-Methyl-2-Phenylethyl)amino]propiononitrile) is a stimulant drug of the phenethylamine and amphetamine chemical classes that was developed in the 1960s.