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Acquired generalized lipodystrophy (AGL), also known as Lawrence syndrome [1] and Lawrence–Seip syndrome, [1] is a rare skin condition that appears during childhood or adolescence, characterized by fat loss affecting large areas of the body, particularly the face, arms, and legs.
A more specific term, lipoatrophy (from Greek lipo 'fat' and dystrophy 'abnormal or degenerative condition'), is used when describing the loss of fat from one area (usually the face). This condition is also characterized by a lack of circulating leptin which may lead to osteosclerosis .
Since 2000, IDSA has recommended against long-term antibiotic treatment for Lyme disease, finding that it is ineffective and potentially harmful. [18] [19] The American Academy of Neurology, Centers for Disease Control and Prevention, National Institutes of Health, and medical groups around the world similarly recommend against such treatment.
[citation needed] The increased prevalence of antibiotic resistance is evident in MRSA species commonly involved in SSSIs, which worsen prognoses and limit treatment options. [citation needed] For less severe infections, microbiologic evaluation using tissue culture has been demonstrated to have high utility in guiding management decisions. [5]
Lipoatrophy is the term describing the localized loss of fat tissue. This may occur as a result of subcutaneous injections of insulin in the treatment of diabetes , from the use of human growth hormone or from subcutaneous injections of copaxone used for the treatment of multiple sclerosis .
Metformin is the main drug used for treatment, as it is normally used for patients with hyperglycemia. [15] Metformin reduces appetite and improves symptoms of hepatic steatosis and polycystic ovary syndrome. [4] Leptin can also be used to reverse insulin resistance and hepatic steatosis, to cause reduced food intake, and decrease blood glucose ...
Open Forum Infectious Diseases (OFID) is a peer-reviewed open-access scientific journal focusing on the field of infectious disease. It is operated by the Infectious Diseases Society of America (IDSA) and HIV Medicine Association and published online-only by Oxford University Press .
The Greek NPHO is a private legal entity that was originally established by Law 4600 in March 2019 (as a legal entity of public law) and took its current form by Law 4633 in October 2019. It is the full successor of the former Center for Diseases Control and Prevention, which was replaced by Law 4600/2019. [ 4 ]