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Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes.It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
OIG reports both to the Secretary of HHS and to the United States Congress about program and management problems and recommendations to correct them. OIG's work is carried out by regional offices nationwide that perform audits , investigations, inspections and other mission-related functions.
The benefits can be substantial, but so can the risks. The possible adverse consequences of genetic tests include discrimination in employment and health insurance and breaches of privacy. Government policies are therefore needed to assure the proper use of genetic tests. The first piece of federal legislation came into effect in 2000.
One outcome has been the growing availability of elective genetic and genomic testing that are initiated by a patient but still ordered by a physician. [10] Additionally, elective genetic and genomic testing that does not require a physician's order called, direct-to-consumer genetic testing has recently entered the testing landscape. [11]
The Department of Defense Inspector General was established in 1982. The mission of DoD IG; as established by the Inspector General Act of 1978, as amended, (5 U.S.C. Appendix); and implemented by DoD Directive 5106.01, "Inspector General of the Department of Defense", is to serve as an independent and objective office in DoD to:
The first whole cancer genome to be sequenced was from cytogenetically normal acute myeloid leukaemia by Ley et al. in November 2008. [5] The first breast cancer tumor was sequenced by Shah et al. in October 2009, [6] the first lung and skin tumors by Pleasance et al. in January 2010, [7] [8] and the first prostate tumors by Berger et al. in ...
The OIG completes these tasks to detect and deter waste, fraud, abuse, and misconduct, and to promote integrity, economy, efficiency, and effectiveness in Department of Justice operations. The Office of the Inspector General (OIG) consists of a front office, which comprises the Inspector General, the Deputy Inspector General, the Office of the ...
The Oncologic Drugs Advisory Committee (ODAC) receives requests for technical and clinical evaluation of new drugs by the U.S. Food and Drug Administration (FDA). The committee, consisting of members from academic and clinical oncology biostatistics, the general public, and the pharmaceutical industry, makes non-binding recommendations to both the CDER and CBER divisions of the FDA about the ...