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Samoyeds can be affected by basement membrane disease of the kidneys. It is inherited through the X chromosome and is therefore more severe in affected male dogs. Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to kidney failure by the age of 9 months and death by 16 months. [3]
These signs and symptoms consist of 1) hematuria- blood in the urine, 2) flank pain – pain in the side due to kidney pain, 3) renal colic – intense, cramping pain due to stones in the urinary tract, 4) obstructive uropathy- urinary tract disease due to obstruction, and 5) urinary tract infections.
It can result in chronic kidney failure, hypoalbuminemia, which can cause ascites and peripheral edema, and nephrotic syndrome, which can cause hypertension or hypercoagulability. [156] Familial renal disease is an uncommon cause of kidney failure in young dogs. Most causes are breed-related (familial) and some are inherited.
Intestinal disease may be related to virus-induced apoptosis (programmed cell death) of cells of the epithelial mucosa of the small intestine. [5] Canine coronavirus was originally thought to cause serious gastrointestinal disease, but now most cases are considered to be very mild or without symptoms. [6]
The disease is specific to the Samoyed, in that the Samoyed is the only breed of dog to show the more rapid progression to kidney failure and death, as well as affecting males to a much more severe degree than females. The Samoyed, however, is not the only breed of dog to suffer from life-threatening renal diseases.
Alabama rot, Greenetrack disease, or cutaneous and renal glomerular vasculopathy (CRGV) [1] is an often fatal condition in dogs. It was first identified in the US in the 1980s in greyhounds. [2] [3] The high number of affected dogs at the Greenetrack Racing Park, Alabama, led to the initial pseudonyms of Greenetrack Disease and Alabama Rot. [4]
Based on analysis of data collected by more than 600 hospitals and clinics in 43 states, out of every 10,000 cats and dogs seen in Banfield clinics, three developed kidney failure during the time pet food contaminated with melamine was on the market. They reported 284 more cases of kidney failure in cats than the expected "background rate ...
The DA2PPC vaccine protects against the debilitating and deadly disease canine distemper. This disease is a fatal viral illness that causes neurologic dysfunction, pneumonia, nonspecific systemic symptoms such as fever and fatigue, and weight loss, as well as upper respiratory symptoms and diarrhea, poor appetite, and vomiting. [4]