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Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of tizanidine in the elderly. However, elderly patients are more likely to have kidney problems, which may require caution in patients receiving this medicine.
Learn about the side effects of tizanidine, from common to rare, for consumers and healthcare professionals.
Common side effects of antispastic and antispasmodic medications include dizziness, drowsiness, and hypotension; therefore, a geriatric patient’s risk for falls and fractures can increase when skeletal muscle relaxants are used.
Seniors may be more susceptible to the side effects of tizanidine. Tizanidine may cause allergic reactions in some people, such as anaphylaxis and urticaria. May interact with several other drugs including those metabolized by hepatic enzymes CYP1A2 (such as fluvoxamine, ciprofloxacin, and some antiarrhythmics), and oral contraceptives.
Common side effects include dry mouth, tiredness, and low energy. Dizziness and low blood pressure are also possible. Rare but serious tizanidine side effects include liver damage and hallucinations. If you want to stop taking tizanidine, talk to your healthcare provider before making any changes.
People who are ages 65 years and older can be at greater risk for some side effects from tizanidine. Talk to your healthcare provider about your risks if you are 65 years and older.
What side effects may I notice from receiving this medication? Side effects that you should report to your care team as soon as possible: Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Tizanidine clearance is reduced by more than 50% in elderly patients with renal insufficiency (creatinine clearance < 25 mL/min) compared to healthy elderly subjects; this would be expected to lead to a longer duration of clinical effect.
Increased side effects can include decreased blood pressure, decreased heart rate, or extreme drowsiness. Using tizanidine with the following drugs can cause excessive sedation...
To make sure tizanidine is safe for you, tell your doctor if you have ever had: low blood pressure. It is not known whether tizanidine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. How should I take tizanidine?