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Alpha-glucosidase inhibitors (AGIs) are oral anti-diabetic drugs used for diabetes mellitus type 2 that work by preventing the digestion of carbohydrates (such as starch and table sugar). They are found in raw plants/herbs such as cinnamon and bacteria (containing the inhibitor acarbose ).
Alpha glucosidase inhibitors delay glucose absorption at the intestine level and thereby prevent sudden surge of glucose after a meal. [ 2 ] There are three major drugs which belong to this class, acarbose , miglitol and voglibose, [ 2 ] of which voglibose is the newest.
Pages in category "Alpha-glucosidase inhibitors" The following 6 pages are in this category, out of 6 total. This list may not reflect recent changes. A. Acarbose;
Generally, drugs outlined within the ATC code A10 should be included in this category. ... Alpha-glucosidase inhibitors (6 P) Amylin receptor agonists (8 P) B.
The A1C test goes by several other names, including: HbA1c test. ... Alpha-glucosidase inhibitors. Biguanides. Dopamine-2 agonists. Dipeptidyl peptidase-4 (DPP-4) inhibitors. Meglitinides.
Acarbose inhibits enzymes (glycoside hydrolases) needed to digest carbohydrates, specifically, alpha-glucosidase enzymes in the brush border of the small intestines, and pancreatic alpha-amylase. It locks up the enzymes by mimicking the transition state of the substrate with its amine linkage. [ 14 ]
Alpha-glucosidase inhibitors are a class of diabetes drugs found in plants/herbs like cinnamon; [3] however, they are technically not hypoglycemic agents because they do not have a direct effect on insulin secretion or sensitivity. These agents slow the digestion of starch in the small intestine, such that glucose from the starch enters the ...
Hence, α-glucosidase inhibitors (like acarbose) are used as anti-diabetic drugs in combination with other anti-diabetic drugs. Luteolin has been found to be a strong inhibitor of α-glucosidase. The compound can inhibit the enzyme up to 36% with a concentration of 0.5 mg/ml. [ 21 ] As of 2016, this substance is being tested in rats, mice and ...