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The survival rate varies for babies born with Edwards syndrome (trisomy 18): Between 60% and 75% survive to their first week. Between 20% and 40% survive to their first month.
The survival percentage is 60% to 75% at the first week, 20% to 40% at one month, and 10% at one year. 5% to 10% of Edwards syndrome patients survive beyond the first year of life. Female infants with Edwards syndrome have greater chances of survival than male infants.
Survival for infants with T13 fell from 74.6% after the first day of life to 25.5% at 28 days. For infants with T18, survival declined from 78.1% after the first day to 37.2% at 28 days. Among the children with T13, 9.7% survived to age 5, whereas 5-year survival for children with T18 was 12.3%.
Among children with T13, 5-year survival was 9.7%; among children with T18, it was 12.3%. For both trisomies, gestational age was the strongest predictor of mortality. Females and children of non-Hispanic black mothers had the lowest mortality.
The median survival was 7 days for trisomy 13 and 29 days for trisomy 18; the figure for trisomy 13 is similar to the prior population studies, but somewhat higher for trisomy 18. 1,5,6.
A recent Japanese study documented the survival rate in a group of trisomy 18 newborn to which intensive care were offered: the median survival time (152.5 days) and survival rate at 12 months [25%] were higher compared to those reported in the previous studies, but the survival over 2 years (4%) was similar to the 5-10% usually reported as 1 ...
Trisomy 18, or Edwards syndrome, occurs when a fetus has an extra chromosome 18. This rare condition can affect development and may have a poor outlook.
We also show improved survival to discharge for patients with trisomy 18 admitted to the hospital, as shown overall nationally and for all regions of the US. The mortality for patients with trisomy 18 who were admitted was between 12% and 19% for the year 2016, depending on the region of the US, and decreased from 21% to 24% for the year 1997.
It is associated with high mortality rates, estimated to be 75%–95% in the first year of life, as well as significant morbidity in survivors. The low survival is largely due to the high prevalence of severe congenital anomalies in infants with this diagnosis.
Trisomy 18 is the second most common aneuploidy syndromes in live born infants. It is associated with high mortality rates, estimated to be 75%-95% in the first year of life, as well as significant morbidity in survivors.