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A good example is the formation of adducts between the Lewis acid borane and the oxygen atom in the Lewis bases, tetrahydrofuran (THF): BH 3 ·O(CH 2) 4 or diethyl ether: BH 3 ·O(CH 3 CH 2) 2. Many Lewis acids and Lewis bases reacting in the gas phase or in non-aqueous solvents to form adducts have been examined in the ECW model. [3]
DNA adduct. In molecular genetics, a DNA adduct is a segment of DNA bound to a cancer-causing chemical. This process could lead to the development of cancerous cells, or carcinogenesis. DNA adducts in scientific experiments are used as biomarkers of exposure. They are especially useful in quantifying an organism's exposure to a carcinogen. [1]
Many adducts violate the octet rule, such as the triiodide anion: I 2 + I − → I − 3. The variability of the colors of iodine solutions reflects the variable abilities of the solvent to form adducts with the Lewis acid I 2. Some Lewis acids bind with two Lewis bases, a famous example being the formation of hexafluorosilicate: SiF 4 + 2 F ...
Crosslinking of DNA. In genetics, crosslinking of DNA occurs when various exogenous or endogenous agents react with two nucleotides of DNA, forming a covalent linkage between them. This crosslink can occur within the same strand (intrastrand) or between opposite strands of double-stranded DNA (interstrand). These adducts interfere with cellular ...
Michael addition reaction. In organic chemistry, the Michael reaction or Michael 1,4 addition is a reaction between a Michael donor (an enolate or other nucleophile) and a Michael acceptor (usually an α,β-unsaturated carbonyl) to produce a Michael adduct by creating a carbon-carbon bond at the acceptor's β-carbon. [1][2] It belongs to the ...
The Baylis–Hillman adducts and their derivatives have been extensively utilized for the generation of heterocycles and other cyclic frameworks. [40] MBH reactions are widely used in organic synthesis. For example, this reaction was used to construct key cyclic intermediates for syntheses of salinosporamide A, diversonol, and anatoxin-a. [41 ...
abducts, intorts, and depress eye. right medial, superior, and inferior recti (superior and inferior oblique muscles are the synergists) 2. 1. oblique, inferior. head, extraocular (left/right) orbital surface of maxilla, lateral to lacrimal groove. laterally onto eyeball, deep to lateral rectus, by a short flat tendon.
Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts — these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA segment that contains ...