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The NSG mouse (NOD scid gamma mouse) is a brand of immunodeficient laboratory mice, developed and marketed by Jackson Laboratory, which carries the strain NOD.Cg- Prkdcscid Il2rgtm1Wjl /SzJ. NSG branded mice are among the most immunodeficient described to date. [1]
The immunodeficient NSG mice enable research in human immune function, infectious disease, diabetes, oncology, and stem cell biology. CD34+ humanized NSG (Stock No. 705557) and PBMC humanized NSG (Stock No. 745557) mice can be ordered on our humanized mouse order form .
NSG™ mouse model variants are the most highly immunodeficient mice and the models of choice for cancer xenograft modeling, stem cell biology, humanized mice, and infectious disease research.
NSG™ mice are more resistant to the toxic side effects of estradiol supplementation compared to other strains, including nude and NOD-scid. This enables long-term study of ER+ breast cancer xenografts. Common questions and answers for maintaining and using NSG™ mice in biomedical research.
NSG ® mouse model variants are the most highly immunodeficient mice and the models of choice for cancer xenograft modelling, stem cell biology, humanised mice, and infectious disease research. Charles River is the exclusive distributor of JAX ® Mice in Europe.
The severe immunodeficiency of NOD.Cg-PrkdcscidIl2rgtm1Wjl (NSG) mice, a widely used strain for generating patient-derived xenografts from primary tumors, impairs drug metabolism and...
The NSG-FLT3 model is the most complete humanized innate immunity cell mouse model from the Jackson Lab to date. This transgenic mouse model has had the endogenous mouse Flt3 receptor knocked out and a human FLT3 ligand expressing transgene knocked in, a critical ligand for immune cell development.
The revolutionary NOD scid gamma (NSG™) mouse model is used by investigators worldwide to advance research in cancer, infectious diseases and a wide array of immunological disorders. NSG™ mice are also routinely used as a preclinical model as “humanized mice” and as a host for human patient-derived cancer xenografts.
Key Benefits. CD34+ engrafted S-15 mice express CD4+, CD8+, and regulatory T cells. CD34+ engrafted S-15 mice express CD33+ myeloid cells, CD14+ monocytes, and CD56 dim +/CD16+ mature natural killer cells. Readily engraftable with human cancer cell line derived and patient derived xenograft for preclinical therapeutic studies. Order Now.
The NSG-SGM3 mouse is a revolutionary in vivo model that allows exceptional engraftment of human tissues including hematopoietic cells. Learn which human cytokines support remarkable engraftment of diverse hematopoietic lineages, primary human AML samples and multiple cancer types compared to other existing models.