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Carcinogenesis: Integrative Cancer Research is a multi-disciplinary journal that brings together all the varied aspects of research that will ultimately lead to the prevention of cancer in humans. Find out more about the benefits of publishing with us here. Introducing Fast Track Review.
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division.
Carcinogenesis refers to the process of transforming normal cells into cancerous ones and has significant clinical implications. The significance of carcinogenesis lies in its profound impact on human health, influencing the diagnosis, treatment, and prevention of cancer.
Using these principles, we have argued that carcinogenesis can be explained as a relational problem whereby release of the constraints created by cell interactions and the physical forces generated by cellular agency lead cells within a tissue to regain their default state of proliferation with variation and motility.
We consider the use of the terms carcinogenesis, cancer inducing factors or carcinogenic factors more adequate for what happens during tumor cell transformation, with the mention that the term carcinogenesis defines the initiation of a tumor, and oncogenesis its maintenance and subsequent evolution.
Carcinogenesis in humans and animals results from the development of a sequence of defects in stem cells which are the targets of transforming agents. 1 In model systems, two general steps in the process of carcinogenesis have been established: initiation and promotion. 2,3 Figure 1 illustrates this concept. For carcinogenesis to develop, stem ...
Introduction. For many decades, a corollary to the contemporary understanding of the nature of cancer and of carcinogenesis has been the recognition of causative agents. Since the 1950s, many agents that contribute to the development of cancer have been categorized as initiators or promoters, on the basis of studies of chemical carcinogenesis ...
In this review, we discuss the carcinogenesis mechanism of ten pathogens, their implications, and some future considerations for better management of the disease. The pathogens and cancers described are Helicobacter pylori (gastric cancer), Epstein-Barr virus (gastric cancer and lymphoma), Hepatitis B and C viruses (liver cancer), Aspergillus spp .
Carcinogenesis, Volume 45, Issue 10, October 2024, Pages 711–720, https://doi.org/10.1093/carcin/bgae057. Allura Red AC is ubiquitous in ultra-processed foods. Despite lacking carcinogen classification, its impact on colon health demands further investigation.
Definition. Carcinogenesis is the process by which cancer develops in various tissues in the body. Characteristics. In most cases carcinogenesis occurs via a stepwise process that can encompass a major fraction of the lifespan (multistep development).