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Antacids are known to interact with several oral medications, including fluoroquinolone and tetracycline antibiotics, iron, itraconazole, and prednisone. [15] Metal chelation is responsible for some of these interactions (e.g. fluoroquinolones , tetracyclines ), leading to decreased absorption of the chelated drug.
The antacids have no interaction between them, so they would be considered to have additive effect when taken together. Drugs that are in the same class, but do not have the same target, may also act additively by interacting with different targets in the same pathway. For example, propofol and sevoflurane can both produce anesthetic effects. [6]
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds ...
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
By knowing the interaction between a certain site of a drug and a receptor, other drugs can be formulated in a way that replicates this interaction, thus producing the same therapeutic effects. Indeed, this method is used to create new drugs. It can help identify which patients are most likely to respond to treatment.
Moxifloxacin has a potential for a serious drug interaction with NSAIDs. [42] The combination of corticosteroids and moxifloxacin has increased potential to result in tendonitis and disability. [43] Antacids containing aluminium or magnesium ions inhibit the absorption of moxifloxacin.
Magaldrate may negatively influence drugs like tetracyclines, benzodiazepines, and indomethacin. High doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence. In some cases it can alter the functionality of the gastrointestinal tract, occasionally provoking constipation or diarrhea.
Roxithromycin is not known to interact with hormonal contraceptives, prednisolone, carbamazepine, ranitidine or antacids. When roxithromycin is administered with theophylline , some studies have shown an increase in the plasma concentration of theophylline .
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