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Common side effects include low blood pressure, skin flushing, and low blood calcium. [1] Other side effects may include vomiting, muscle weakness, and decreased breathing. [4] While there is evidence that use during pregnancy may harm the baby, the benefits in certain conditions are greater than the risks. [5]
Commonly used tocolytic medications include β 2 agonists, calcium channel blockers, NSAIDs, and magnesium sulfate. These can assist in delaying preterm delivery by suppressing uterine muscle contractions and their use is intended to reduce fetal morbidity and mortality associated with preterm birth. [ 2 ]
As a bronchodilator after beta-agonist and anticholinergic agents have been tried, e.g. in severe exacerbations of asthma. [4]Obstetrics: Magnesium sulfate is used to prevent seizures in women with preeclampsia and eclampsia, and is also used for fetal neuroprotection in preterm deliveries, but has been shown to be an ineffective tocolytic agent.
In general, the treatment of postpartum preeclampsia is the same as during pregnancy, including using anti-hypertensive medications to lower blood pressure and magnesium sulfate to prevent eclampsia. The same blood pressure medications that are used during pregnancy can be used in the postpartum period.
Magnesium sulfate is used in obstetrics for premature labor and preeclampsia. [7] Memantine (Namenda) for OCD: memantine is approved for the treatment of Alzheimer's disease. Methotrexate (MTX), approved for the treatment of choriocarcinoma, is frequently used for the medical treatment of an unruptured ectopic pregnancy. [14]
Magnesium sulfate or magnesium sulphate is a chemical compound, a salt with the formula MgSO 4, consisting of magnesium cations Mg 2+ (20.19% by mass) and sulfate anions SO 2− 4. It is a white crystalline solid , soluble in water but not in ethanol .
The structures of solid magnesium citrates have been characterized by X-ray crystallography.In the 1:1 salt, only one carboxylate of citrate is deprotonated. It has the formula Mg(H 2 C 6 H 5 O 7) 2 The other form of magnesium citrate has the formula Mg(HC 6 H 5 O 7)(H 2 O) 2, consisting of the citrate dianion (both carboxylic acids are deprotonated). [1]
The study demonstrating the effectiveness of magnesium sulfate for the management of eclampsia was first published in 1955. [57] Effective anticonvulsant serum levels range from 2.5 to 7.5 mEq/L, [ 58 ] however the ideal dosing regime (dose, route of administration, timing of dosing) to prevent and treat eclampsia is not clear.
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