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  2. Sirtris Pharmaceuticals - Wikipedia

    en.wikipedia.org/wiki/Sirtris_Pharmaceuticals

    Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. Conceived in 2004 by Harvard University biologist David Sinclair and Andrew Perlman, [1] and founded that year by Sinclair and Perlman, along with Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, [2] the company was ...

  3. David A. Sinclair - Wikipedia

    en.wikipedia.org/wiki/David_A._Sinclair

    David Andrew Sinclair AO (born June 26, 1969) is an Australian-American biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and the founding director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard.

  4. Resveratrol - Wikipedia

    en.wikipedia.org/wiki/Resveratrol

    A review of 136 patients in seven studies who were given more than 500 mg for a month showed 25 cases of diarrhea, 8 cases of abdominal pain, 7 cases of nausea, and 5 cases of flatulence. [52] A 2018 review of resveratrol effects on blood pressure found that some people had increased frequency of bowel movements and loose stools. [16]

  5. List of scientific misconduct incidents - Wikipedia

    en.wikipedia.org/wiki/List_of_scientific...

    A Lancet review on Handling of Scientific Misconduct in Scandinavian countries gave examples of policy definitions. In Denmark, scientific misconduct is defined as "intention[al] negligence leading to fabrication of the scientific message or a false credit or emphasis given to a scientist", and in Sweden as "intention[al] distortion of the ...

  6. Timeline of aging research - Wikipedia

    en.wikipedia.org/wiki/Timeline_of_aging_research

    In January, a team led by David Sinclair shows in a 13-year-long international study how DNA breaks or epigenetic damage are a major driver of epigenetic change, and how the loss of epigenetic information is a cause of aging in mammals. It concluded that the loss of epigenetic information can drive aging independently of changes to the genetic ...

  7. Lifespan: Why We Age – and Why We Don't Have To - Wikipedia

    en.wikipedia.org/wiki/Lifespan:_Why_We_Age...

    Lifespan debuted at #11 on The New York Times hardcover nonfiction bestseller list on September 28, 2019. [1]The book received mixed reviews from critics. "If you're even mildly hopeful about dunking a basketball at the age of 50, or hiking the Appalachian Trail at 70, or blowing 100 candles out on your birthday cake someday, you might consider making room for Lifespan on your bookshelf," one ...

  8. Leonard P. Guarente - Wikipedia

    en.wikipedia.org/wiki/Leonard_P._Guarente

    In 1991 his lab started to study genes involved in aging. [5] In 1993, Cynthia Kenyon 's lab at UCSF discovered that a single-gene mutation in ( Daf-2 ) could double the lifespan of C. elegans . That same year, David Sinclair joined the Guarente lab, and they developed the hypothesis that caloric restriction slows aging by activation of ...

  9. Aubrey de Grey - Wikipedia

    en.wikipedia.org/wiki/Aubrey_de_Grey

    Aubrey David Nicholas Jasper de Grey (/ d ə ˈ ɡ r eɪ /; born 20 April 1963) is an English biomedical gerontologist. He is the author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). De Grey is known for his view that medical technology may enable human beings alive today not to die from age ...

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