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  2. Endothelial NOS - Wikipedia

    en.wikipedia.org/wiki/Endothelial_NOS

    eNOS is a dimer containing two identical monomers of 140 kD constituted by a reductase domain, which displays binding sites for nicotinamide adenine dinucleotide phosphate (NADPH), flavin mononucleotide (FMN), and flavin adenine dinucleotide (FAD), and an oxidase domain, which displays binding sites for heme group, zinc, the cofactor tetrahydrobiopterin (), and the substrate L-arginine. [13]

  3. Riociguat - Wikipedia

    en.wikipedia.org/wiki/Riociguat

    Riociguat, sold under the brand name Adempas, is a medication by Bayer that is a stimulator of soluble guanylate cyclase (sGC). It is used to treat two forms of pulmonary hypertension (PH): chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH).

  4. Beta3-adrenergic agonist - Wikipedia

    en.wikipedia.org/wiki/Beta3-adrenergic_agonist

    Another mechanism by which β 3-AR agonists exert their relaxative effects on vasculature is by promoting endothelial nitric oxide synthase (eNOS) activity and NO bioavailability. [15] This is believed to be the mechanism by which nebivolol, a selective β 1-AR antagonist with additional β 3-AR agonist activity, exerts its cardio-protective ...

  5. Nitric oxide synthase - Wikipedia

    en.wikipedia.org/wiki/Nitric_oxide_synthase

    Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). [2] The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired ...

  6. Endothelium-derived hyperpolarizing factor - Wikipedia

    en.wikipedia.org/wiki/Endothelium-derived...

    The endothelium maintains vascular homeostasis through the release of active vasodilators.Although nitric oxide (NO) is recognized as the primary factor at level of arteries, increased evidence for the role of another endothelium-derived vasodilator known as endothelium-derived hyperpolarizing factor (EDHF) has accumulated in the last years.

  7. WIN 55,212-2 - Wikipedia

    en.wikipedia.org/wiki/WIN_55,212-2

    WIN 55,212-2 is a full agonist at the CB 1 cannabinoid receptor (K i = 1.9 nM) and has much higher affinity than THC (K i = 41 nM) for this receptor. [11] WIN 55,212-2 is also an agonist of the PPARα and PPARγ nuclear receptors.

  8. Beta-adrenergic agonist - Wikipedia

    en.wikipedia.org/wiki/Beta-adrenergic_agonist

    Beta adrenergic agonists or beta agonists are medications that relax muscles of the airways, causing widening of the airways and resulting in easier breathing. [1] They are a class of sympathomimetic agents, each acting upon the beta adrenoceptors . [ 2 ]

  9. Histamine H1 receptor - Wikipedia

    en.wikipedia.org/wiki/Histamine_H1_receptor

    The H 1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.This receptor is activated by the biogenic amine histamine.It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system.