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Physical biochemistry is a branch of biochemistry that deals with the theory, techniques, and methodology used to study the physical chemistry of biomolecules. [1] It also deals with the mathematical approaches for the analysis of biochemical reaction and the modelling of biological systems.
Basic units of chromatin structure. Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells. [1] [2] Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure.
Vincent Allfrey and Alfred Mirsky had earlier proposed a role of histone modification in transcriptional activation, [125] regarded as a molecular manifestation of epigenetics. Michael Grunstein [ 126 ] and David Allis [ 127 ] found support for this proposal, in the importance of histone acetylation for transcription in yeast and the activity ...
Histone H4 is a 102 to 135 amino acid protein which shares a structural motif, known as the histone fold, formed from three a-helices connected by two loops.Histone proteins H3 and H4 bind to form a H3-H4 dimer, two of these H3-H4 dimers combine to form a tetramer.
In molecular biology, BAR domains are highly conserved protein dimerisation domains that occur in many proteins involved in membrane dynamics in a cell. The BAR domain is banana-shaped and binds to membrane via its concave face.
Agarose is a linear polymer with a molecular weight of about 120,000, consisting of alternating D-galactose and 3,6-anhydro-L-galactopyranose linked by α-(1→3) and β-(1→4) glycosidic bonds. The 3,6-anhydro- L -galactopyranose is an L -galactose with an anhydro bridge between the 3 and 6 positions, although some L -galactose units in the ...
Molecular Biology of the Cell has been described as "the most influential cell biology textbook of its time". [2] The sixth edition is dedicated to the memory of co-author Julian Lewis, who died in early 2014. The book was the first to position cell biology as a central discipline for biology and medicine, and immediately became a landmark ...
The central principle of biology showing the flow of information from DNA to the phenotype. Associated with each stage is the corresponding systems biology tool, from genomics to metabolomics. Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell ...