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Use of antidepressants during pregnancy may result in fetus abnormalities affecting functional development of the brain and behavior. [89] Studies have shown correlations between pregnant women treated with SNRIs and risk of hypertensive disorders, [90] preeclampsia, [91] miscarriage, [92] seizures in children, [93] and many other adverse affects.
Moclobemide is regarded as a generally safe antidepressant and due to its favorable side effect profile, it can be considered a first-line therapeutic antidepressant. [56] The rate of incidence of side effects of moclobemide is low, [ 23 ] with insomnia , headache and dizziness being the most commonly reported side effects in the initial stages ...
Vortioxetine, sold under the brand name Trintellix (in the US) and Brintellix (in the EU) among others, is an antidepressant of the serotonin modulator and stimulator (SMS) class. [15] [3] Its effectiveness is viewed as similar to that of other antidepressants. [15] It is taken orally. [15]
Tricyclic antidepressants are older antidepressants that, due to their side effect profiles, typically aren’t prescribed as first-line depression treatments today.
Milnacipran should not be used during pregnancy because it may cross the placenta barrier and no clinical data exists on harmful effects in humans and animal studies. Milnacipran is contraindicated during lactation because it is excreted in the milk, and it is not known if it is harmful to the newborn.
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When Meghan Trainor gave birth, her son Riley was rushed to the NICU. “(Nurses) kept asking me if I was on antidepressants during the pregnancy," she recalled.
Nortriptyline may cause problems if taken during pregnancy. [8] Use during breastfeeding appears to be relatively safe. [7] It is a tricyclic antidepressant (TCA) and is believed to work by altering levels of serotonin and norepinephrine. [8] Nortriptyline was approved for medical use in the United States in 1964. [8]
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