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Monocytes will then develop into macrophages or dendritic cells upon tissue damage and recruitment of monocytes into the infected area. [1] During recruitment monocytes are distinct from macrophages and dendritic cells, but upon entering the infected area, monocytes will acquire inflammatory effector functions and then differentiate into ...
Monocytes can migrate into tissues and replenish resident macrophage populations. Macrophages have a high antimicrobial and phagocytic activity and thereby protect tissues from foreign substances. They are cells that possess a large smooth nucleus, a large area of cytoplasm, and many internal vesicles for processing foreign material.
The monocyte is formed in the bone marrow and transported by the blood; it migrates into the tissues, where it transforms into a histiocyte or a macrophage. Macrophages are diffusely scattered in the connective tissue and in liver (Kupffer cells), spleen and lymph nodes (sinus histiocytes), lungs (alveolar macrophages), and central nervous ...
Leukocyte extravasation describes monocyte entry into damaged tissue through the endothelium of blood vessels as they become macrophages. Monocytes are attracted to a damaged site by chemical substances through chemotaxis, triggered by a range of stimuli including damaged cells, pathogens and cytokines released
[1] [2] Undifferentiated bone marrow cells are cultured in the presence of macrophage colony-stimulating factor (M-CSF; CSF-1). [3] M-CSF is a cytokine and growth factor that is responsible for the proliferation and commitment of myeloid progenitors into monocytes (which then mature into macrophages).
Since all previous researchers have indicated that epithelioid cells are formed from monocytes, and monocytes and macrophages were combined into a single mononuclear phagocyte system, Van Furth et al. (1972), referring to the work of Sutton J. and Weiss L. (1966), [6] formally attributed epithelioid cells to the mononuclear phagocyte system. [2]
CFU-GM (Colony Forming Unit–Granulocyte–Macrophage [a]), also known as granulocyte–macrophage progenitor (GMP), is a colony forming unit. It is derived from CFU-GEMM. It is the precursor for monoblasts and myeloblasts. Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).
Their main function is the storage of lipid. Macrophages arise from monocytes. Monocytes originate in the bone marrow upon which they are released into the blood stream. They are mobile and leave the blood stream to enter connective tissues where they differentiate into macrophages. The fibroblasts are the most important in the connective tissue.
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