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Leucine (symbol Leu or L) [3] is an essential amino acid that is used in the biosynthesis of proteins.Leucine is an α-amino acid, meaning it contains an α-amino group (which is in the protonated −NH 3 + form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO − form under biological conditions), and a side chain isobutyl group, making it a non ...
Levacetylleucine. Levacetylleucine, sold under the brand name Aqneursa, is a medication used for the treatment of neurological manifestations of Niemann-Pick disease type C. [1][2] Levacetylleucine is a modified version of the amino acid leucine (N-Acetyl-L-Leucine). [1] It is taken by mouth.
β-Hydroxy β-methylbutyric acid [note 1] (HMB), otherwise known as its conjugate base, β-hydroxy β-methylbutyrate, is a naturally produced substance in humans that is used as a dietary supplement and as an ingredient in certain medical foods that are intended to promote wound healing and provide nutritional support for people with muscle wasting due to cancer or HIV/AIDS.
The endogenous α-amino acids L-leucine and L-isoleucine, which closely resemble pregabalin and the other gabapentinoids in chemical structure, are apparent ligands of the α 2 δ VDCC subunit with similar affinity as the gabapentinoids (e.g., IC 50 =71 nM for L-isoleucine), and are present in human cerebrospinal fluid at micromolar ...
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Acetylleucine (N-acetyl-leucine) is a modified leucine amino acid used in the treatment of vertigo [2] and cerebellar ataxia. Two forms exist: acetyl- DL -leucine (sold under the brand Tanganil, among others) and N -acetyl- L ...
HEDIS 2006 Volume 2: Technical Specifications. The Healthcare Effectiveness Data and Information Set (HEDIS) is a widely used set of performance measures in the managed care industry, developed and maintained by the National Committee for Quality Assurance (NCQA). HEDIS was designed to allow consumers to compare health plan performance to other ...
α-Ketoisocaproic acid (α-KIC), also known as 4-methyl-2-oxovaleric acid, and its conjugate base and carboxylate, α-ketoisocaproate, are metabolic intermediates in the metabolic pathway for L -leucine. [2] Leucine is an essential amino acid, and its degradation is critical for many biological duties. [3] α-KIC is produced in one of the first ...
An essential amino acid, or indispensable amino acid, is an amino acid that cannot be synthesized from scratch by the organism fast enough to supply its demand, and must therefore come from the diet. Of the 21 amino acids common to all life forms, the nine amino acids humans cannot synthesize are valine, isoleucine, leucine, methionine ...