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Human iron metabolism is the set of chemical reactions that maintain human homeostasis of iron at the systemic and cellular level. Iron is both necessary to the body and potentially toxic. Controlling iron levels in the body is a critically important part of many aspects of human health and disease.
The human body's rate of iron absorption appears to respond to a variety of interdependent factors, including total iron stores, the extent to which the bone marrow is producing new red blood cells, the concentration of hemoglobin in the blood, and the oxygen content of the blood.
Parts-per-million cube of relative abundance by mass of elements in an average adult human body down to 1 ppm. About 99% of the mass of the human body is made up of six elements: oxygen, carbon, hydrogen, nitrogen, calcium, and phosphorus. Only about 0.85% is composed of another five elements: potassium, sulfur, sodium, chlorine, and magnesium ...
Iron helps to strengthen the body's resistance to infections and diseases by facilitating the growth and health of immune cells. So, it is vital for the proper functioning of the immune system.
Roughly 5 grams of iron are present in the human body and is the most abundant trace metal. [1] It is absorbed in the intestine as heme or non-heme iron depending on the food source. Heme iron is derived from the digestion of hemoproteins in meat. [4] Non-heme iron is mainly derived from plants and exist as iron(II) or iron(III) ions. [4]
The four organogenic elements, namely carbon, hydrogen, oxygen, and nitrogen , that comprise roughly 96% of the human body by weight, [7] are usually not considered as minerals (nutrient). In fact, in nutrition, the term "mineral" refers more generally to all the other functional and structural elements found in living organisms.
The human body has no controlled mechanism for excretion of iron. [23] This can lead to iron overload problems in patients treated with blood transfusions, as, for instance, with β-thalassemia. Iron is actually excreted in urine [24] and is also concentrated in bile [25] which is excreted in feces. [26]
The body of an adult human contains about 4 grams (0.005% body weight) of iron, mostly in hemoglobin and myoglobin. These two proteins play essential roles in oxygen transport by blood and oxygen storage in muscles. To maintain the necessary levels, human iron metabolism requires a minimum of iron in the diet.