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Premature adrenarche is the most common cause of the early appearance of pubic hair ("premature pubarche") in childhood. In a large proportion of children it seems to be a variation of normal development requiring no treatment. However, there are three clinical issues related to premature adrenarche.
In clinical circumstances this form of CAH has sometimes been difficult to distinguish from the more common 21-hydroxylase deficient CAH because of the 17α-hydroxypregnenolone elevation, or from simple premature adrenarche because of the DHEA elevation. [citation needed]
The growth problem is even worse in the simple virilizing forms of CAH which are detected when premature pubic hair appears in childhood because the bone age is often several years advanced at the age of diagnosis. While a boy (or girl) with simple virilizing CAH is taller than peers at that point, he will have far fewer years remaining to grow ...
The study highlights racial and age disparities, particularly in the increased numbers of preterm births for the Black and Hispanic communities. US sees a 12% surge in premature births, CDC data ...
Late onset congenital adrenal hyperplasia (LOCAH), also known as nonclassic congenital adrenal hyperplasia (NCCAH or NCAH), is a milder form of congenital adrenal hyperplasia (CAH), [1] a group of autosomal recessive disorders characterized by impaired cortisol synthesis that leads to variable degrees of postnatal androgen excess.
Triplet and higher multiple births nosedive. In 2004, of the people younger than 35 who gave birth with the help of IVF, 32.7% delivered twins, and 4.9% delivered triplets, according to doctors at ...
The gene MKRN3, which is a maternally imprinted gene, was first cloned by Jong et al. in 1999. MKRN3 was originally named Zinc finger protein 127. It is located on human chromosome 15 on the long arm in the Prader-Willi syndrome critical region2, and has since been identified as a cause of premature sexual development or CPP. [32]
The U.S. Centers for Disease Control and Prevention and other federal health agencies on Friday took down webpages with information on HIV statistics and other data to comply with Trump ...