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Achieving optimal eradication of H. pylori has proven difficult. Combination regimens that use two or three antibiotics with a proton pump inhibitor and/or bismuth are required to achieve adequate rates of eradication and to reduce the number of failures due to antibiotic resistance. In the United States, up to 50% of strains are resistant to ...
Vonoprazan, sold under the brand name Voquezna among others, is a first-in-class potassium-competitive acid blocker medication. [2] [1] Vonoprazan is used in form of the fumarate for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori.
Several anti-ulcer dosing regimens that combine antibiotics and proton pump inhibitors (PPI) to treat helicobacter pylori (H. pylori) induced peptic ulcer disease (PUD). The role of antibiotic in the therapies is to eradicate H. pylori, while the action of PPI is to reduce gastric acid secretion. The anti-ulcer dosing regimens generally repair ...
In general, proton pump inhibitors are well tolerated, and the incidence of short-term adverse effects is relatively low. The range and occurrence of adverse effects are similar for all of the PPIs, though they have been reported more frequently with omeprazole. This may be due to its longer availability and, hence, clinical experience.
The side effect profile is similar to that of omeprazole and other commonly used PPIs. [26] The most common side effects include headache, nausea, and diarrhea. [2] Rare side effects include rashes, flu-like symptoms, and infections (including by the gastrointestinal pathogen Clostridioides difficile [27]). [26]
[3] [4] [5] Its usefulness in people infected by H. pylori is limited. [3] It is used by mouth (for upper GIT ulcers) and rectally (for radiation proctitis). [3] [5] Common side effects include constipation. [3] Serious side effects may include bezoar formation and encephalopathy. [6] Use appears to be safe in pregnancy and breastfeeding. [6]
Carbon urea breath tests have a high sensitivity and specificity for the diagnosis of H. pylori. [136] Proton-pump inhibitors and antibiotics should be discontinued for at least 30 days prior to testing for H. pylori infection or eradication, as both agents inhibit H. pylori growth and may lead to false negative results. [135]
Lansoprazole is used for treatment of: [3] Ulcers of the stomach and duodenum, and NSAID-induced ulcers; Helicobacter pylori infection, alongside antibiotics (adjunctive treatment), treatment to kill H. pylori causing ulcers or other problems involves using two other drugs besides lansoprazole known as "triple therapy", and involves taking twice daily for 10 or 14 days lansoprazole ...